Bioinspired scaffold induced regeneration of neural tissue

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dc.authorid0000-0003-0352-1947
dc.contributor.authorAltun, Esra
dc.contributor.authorAydoğdu, Mehmet Onur
dc.contributor.authorToğay, Sine Özmen
dc.contributor.authorŞengil, Ahmet Zeki
dc.contributor.authorEkren, Nazmi
dc.contributor.authorErginer Hasköylü, Merve
dc.contributor.authorToksoy Öner, Ebru
dc.contributor.authorAltuncu, Neşe A.
dc.contributor.authorÖztürk, Gürkan
dc.contributor.authorCrabbe-Mann, Maryam
dc.contributor.authorAhmed, Jubair
dc.contributor.authorGündüz, Oğuzhan
dc.contributor.authorEdirisinghe, Mohan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:34Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:34Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.descriptionWOS: 000467668800012
dc.description.abstractIn the last decade, nerve tissue engineering has attracted much attention due to the incapability of self-regeneration. Nerve tissue regeneration is mainly based on scaffold induced nanofibrous structures using both bio and synthetic polymers. The produced nanofibrous scaffolds have to be similar to the natural extracellular matrix and should provide an appropriate environment for cells to attach onto. Nanofibrous scaffolds can support or regenerate cells of tissue. Electrospinning is an ideal method for producing the nanofibrous scaffolds. In this study, Bacterial cellulose (BC)/Poly (epsilon-caprolactone) (PCL) blend nanofibrous scaffolds were successfully prepared by electrospinning for nerve tissue induced repair. The produced nanofibrous scaffolds contain well defined interconnected nanofiber networks with hollow micro/nanobeads. Firstly, in-vitro biocompatibilities of nanofibrous scaffolds were tested with L2929 murine fibroblasts and improved cell adhesion and proliferation was observed with polymer blends compared with PCL only. The primary cell culture was performed with dorsal root ganglia (DRG) cells on nanofibrous samples and the samples were found suitable for enhancing neural growth and neurite outgrowth. Based on these results, the BC/PCL (50:50 wt%) nanofibrous scaffolds exhibited nerve-like branching and are excellent candidate for potential biomimetic applications in nerve tissue engineering regeneration.
dc.identifier.citationAltun, E., Aydoğdu, M. O., Toğay, S. Ö., Şengil, A. Z., Ekren, N., Erginer Hasköylü, M. ... Edirisinghe, M. (2019). Bioinspired scaffold induced regeneration of neural tissue. European Polymer Journal, 114, 98-108. https://dx.doi.org/10.1016/j.eurpolymj.2019.02.008
dc.identifier.doi10.1016/j.eurpolymj.2019.02.008
dc.identifier.endpage108
dc.identifier.issn0014-3057
dc.identifier.issn1873-1945
dc.identifier.scopusqualityQ1
dc.identifier.startpage98
dc.identifier.urihttps://dx.doi.org/10.1016/j.eurpolymj.2019.02.008
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1659
dc.identifier.volume114
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofEuropean Polymer Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBacterial Cellulose
dc.subjectPolycaprolactone
dc.subjectElectrospinning
dc.subjectNerve Regeneration
dc.subjectBiomimetic
dc.titleBioinspired scaffold induced regeneration of neural tissue
dc.typeArticle

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