Classification of Parkinson's disease with dementia using phase locking factor of event-related oscillations to visual and auditory stimuli
| dc.authorid | 0000-0002-7715-3035 | |
| dc.authorid | 0000-0002-7555-3801 | |
| dc.authorid | 0000-0002-0860-0524 | |
| dc.contributor.author | Tülay, Emine Elif | |
| dc.contributor.author | Yıldırım, Ebru | |
| dc.contributor.author | Aktürk, Tuba | |
| dc.contributor.author | Güntekin, Bahar | |
| dc.date.accessioned | 2023-05-02T13:26:04Z | |
| dc.date.available | 2023-05-02T13:26:04Z | |
| dc.date.issued | 2023 | |
| dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) | |
| dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü | |
| dc.department | İstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Elektronörofizyoloji Ana Bilim Dalı | |
| dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı | |
| dc.description.abstract | Objective. In the last decades, machine learning approaches have been widely used to distinguish Parkinson’s disease (PD) and many other neuropsychiatric diseases. They also speed up the clinicians and facilitate decision-making for several conditions with similar clinical symptoms. The current study attempts to detect PD with dementia (PDD) by event-related oscillations (EROs) during cognitive processing in two modalities, i.e. auditory and visual. Approach. The study was conducted to discriminate PDD from healthy controls (HC) using event-related phase-locking factors in slow frequency ranges (delta and theta) during visual and auditory cognitive tasks. Seventeen PDD and nineteen HC were included in the study, and linear discriminant analysis was used as a classifier. During classification analysis, multiple settings were implemented by using different sets of channels (overall, fronto-central and temporo-parieto-occipital (TPO) region), frequency bands (delta-theta combined, delta, theta, and low theta), and time of interests (0.1-0.7 s, 0.1-0.5 s and 0.1-0.3 s for delta, delta-theta combined; 0.1-0.4 s for theta and low theta) for spatial-spectral-temporal searchlight procedure. Main results. The classification performance results of the current study revealed that if visual stimuli are applied to PDD, the delta and theta phase-locking factor over fronto-central region have a remarkable contribution to detecting the disease, whereas if auditory stimuli are applied, the phase-locking factor in low theta over TPO and in a wider range of frequency (1-7 Hz) over the fronto-central region classify HC and PDD with better performances. Significance. These findings show that the delta and theta phase-locking factor of EROs during visual and auditory stimuli has valuable contributions to detecting PDD. | |
| dc.identifier.citation | Tülay, E. E., Yıldırım, E., Aktürk, T. ve Güntekin, B. (2023). Classification of Parkinson's disease with dementia using phase locking factor of event-related oscillations to visual and auditory stimuli. Journal of Neural Engineering, 20(2), https://doi.org/10.1088/1741-2552/acc612 | |
| dc.identifier.doi | 10.1088/1741-2552/acc612 | |
| dc.identifier.issn | 1741-2560 | |
| dc.identifier.issn | 1741-2552 | |
| dc.identifier.issue | 2 | |
| dc.identifier.pmid | 36944236 | |
| dc.identifier.scopus | 2-s2.0-85151573923 | |
| dc.identifier.scopusquality | Q1 | |
| dc.identifier.uri | https://doi.org/10.1088/1741-2552/acc612 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/10913 | |
| dc.identifier.volume | 20 | |
| dc.identifier.wos | 000961153200001 | en_US |
| dc.identifier.wosquality | Q2 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.institutionauthor | Yıldırım, Ebru | |
| dc.institutionauthor | Aktürk, Tuba | |
| dc.institutionauthor | Güntekin, Bahar | |
| dc.language.iso | en | |
| dc.publisher | IOP Publishing Ltd | |
| dc.relation.ispartof | Journal of Neural Engineering | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | Attribution 4.0 International | * |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject | Classification | |
| dc.subject | Delta | |
| dc.subject | Inter-Trial Phase Coherence | |
| dc.subject | Linear Discriminant Analysis | |
| dc.subject | Parkinson’s Disease With Dementia | |
| dc.subject | Theta | |
| dc.title | Classification of Parkinson's disease with dementia using phase locking factor of event-related oscillations to visual and auditory stimuli | |
| dc.type | Article |
