MCH neuron activity ıs sufficient for reward and reinforces feeding

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dc.authorid0000-0002-3247-613X
dc.authorid0000-0003-4604-4765
dc.authorid0000-0002-3325-8820
dc.contributor.authorDilsiz, Pelin
dc.contributor.authorAklan, İltan
dc.contributor.authorSayar Atasoy, Nilufer
dc.contributor.authorYavuz, Yavuz
dc.contributor.authorFiliz, Gizem
dc.contributor.authorKöksalar, Fulya
dc.contributor.authorAteş, Tayfun
dc.contributor.authorÖncül, Merve
dc.contributor.authorÇoban, İlknur
dc.contributor.authorAteş Öz, Edanur
dc.contributor.authorCebecioğlu, Utku
dc.contributor.authorAlp, Muhammed İkbal
dc.contributor.authorYılmaz, Bayram
dc.contributor.authorAtasoy, Deniz
dc.date.accessioned2020-05-08T09:24:14Z
dc.date.available2020-05-08T09:24:14Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.description.abstractBackground: Melanin-concentrating hormone (MCH)-expressing neurons have been implicated in regulation of energy homeostasis and reward, yet the role of their electrical activity in short-term appetite and reward modulation has not been fully understood. Objectives: We investigated short-term behavioral and physiological effects of MCH neuron activity manipulations. Methods: We used optogenetic and chemogenetic approaches in Pmch-cre transgenic mice to acutely stimulate/inhibit MCH neuronal activity while probing feeding, locomotor activity, anxiety-like behaviors, glucose homeostasis, and reward. Results: MCH neuron activity is neither required nor sufficient for short-term appetite unless stimulation is temporally paired with consumption. MCH neuronal activation does not affect short-term locomotor activity, but inhibition improves glucose tolerance and is mildly anxiolytic. Finally, using two different operant tasks, we showed that activation of MCH neurons alone is sufficient to induce reward. Conclusions: Our results confirm diverse behavioral/physiological functions of MCH neurons and suggest a direct role in reward function.
dc.description.sponsorshipEMBO IG grant [2539]en_US
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [214S0859999]en_US
dc.identifier.citationDilsiz, P., Aklan, İ., Sayar Atasoy, N., Yavuz, Y., Filiz, G., Köksalar, F. ... Atasoy, D.(2020). MCH neuron activity ıs sufficient for reward and reinforces feeding. Neuroendocrinology, 110(3-4), 258-270. https://dx.doi.org/10.1159/000501234
dc.identifier.doi10.1159/000501234
dc.identifier.endpage270
dc.identifier.issn0028-3835
dc.identifier.issn1423-0194
dc.identifier.issue45385
dc.identifier.scopusqualityQ1
dc.identifier.startpage258
dc.identifier.urihttps://dx.doi.org/10.1159/000501234
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5215
dc.identifier.volume110
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKarger
dc.relation.ispartofNeuroendocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectMelanin-Concentrating Hormone
dc.subjectReward
dc.subjectOptogenetics
dc.subjectChemogenetics
dc.subjectGlucose Homeostasis
dc.titleMCH neuron activity ıs sufficient for reward and reinforces feeding
dc.typeArticle

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