Red blood cell distribution width in patients with chronic obstructive pulmonary disease and healthy subjects

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dc.authorid0000-0001-6639-2797
dc.authorid0000-0002-6952-3470
dc.contributor.authorÖzgül, Güler
dc.contributor.authorSeyhan, Ekrem Cengiz
dc.contributor.authorÖzgül, Mehmet Akif
dc.contributor.authorGünlüoğlu, Mehmet Zeki
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:30Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:30Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göğüs Cerrahisi Ana Bilim Dalı
dc.description.abstractBackground Chronic obstructive pulmonary disease (COPD) increases the risk of cardiovascular disease (CVD). Red blood cell distribution width (RDW) is accepted as a powerful predictor of outcomes in patients with CVD. Aims To study RDW in patients with COPD, and to compare the value of this measurement with clinical, echocardiographic, nutritional and laboratory status. Secondly, we aimed to determine the effect of smoking on RDW values in healthy subjects. Methods One hundred and seventy-five patients with stable COPD and 210 healthy controls were enrolled in the study. Demographic, clinical, nutritional status, echocardiographic, and laboratory characteristics, RDW values were recorded and compared. Results RDW values were higher in the COPD group than in controls (15±2.3% vs 13.8±2.5%, p<0.001). In COPD patients, RDW levels positively correlated with CRP levels (r=0.27, p<.001), albumin levels (r=0.23, P=.04), right ventricular dysfunction (RVD) (r=0.24, P=.001), pulmonary hypertension (PAH) (r=0.1, P=.02), and presence of CVD (r=0.24, P=.02). In multivariable logistic regression suggested that presence of CVD (4.3; 95% CI: 1.3–11; P=.01), and presence of RVD (3.1; 95% CI: 1.7–8.3; P=.02) were independently related to elevated RDW levels in COPD patients. In the healthy population, correlations analysis showed only a significant correlation between RDW and cigarette smoking years (r=0.57, p<.001). Conclusion RDW is independently associated with CVD and RVD in patients with COPD. In the healthy population, RDW is also associated with smoking status.
dc.identifier.citationÖzgül, G., Seyhan, E. C., Özgül, M. A. ve Günlüoğlu, M. Z. (2017). Red blood cell distribution width in patients with chronic obstructive pulmonary disease and healthy subjects. Archivos de Bronconeumologia, 53(3), 107-113. https://dx.doi.org/10.1016/j.arbr.2016.06.027
dc.identifier.doi10.1016/j.arbr.2016.06.027
dc.identifier.endpage113
dc.identifier.issn0300-2896
dc.identifier.issn1579-2129
dc.identifier.issue3
dc.identifier.scopusqualityQ3
dc.identifier.startpage107
dc.identifier.urihttps://hdl.handle.net/20.500.12511/817
dc.identifier.urihttps://dx.doi.org/10.1016/j.arbr.2016.06.027
dc.identifier.volume53
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Doyma Sl.
dc.relation.ispartofArchivos de Bronconeumologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectCardiovascular Disease
dc.subjectChronic Obstructive Pulmonary Disease
dc.subjectInflammation Marker
dc.subjectRed Blood Cell Distribution Width
dc.titleRed blood cell distribution width in patients with chronic obstructive pulmonary disease and healthy subjects
dc.title.alternativeAmplitud de distribución eritrocitaria en pacientes con enfermedad pulmonar obstructiva crónica y en sujetos sanos
dc.typeArticle

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