Rethinking isolated cleft lip and palate as a syndrome

Basit Öğe Kaydı
dc.authorid0000-0002-8440-367X
dc.authorid0000-0002-5767-1791
dc.contributor.authorKoruyucu, Mine
dc.contributor.authorKasımoğlu, Yelda
dc.contributor.authorSeymen, Figen
dc.contributor.authorBayram, Merve
dc.contributor.authorPatır Münevveroğlu, Aslı
dc.contributor.authorErgöz, Nihan
dc.contributor.authorTuna, Elif Bahar
dc.contributor.authorGencay, Koray
dc.contributor.authorDeeley, Kathleen
dc.contributor.authorBussaneli, Diego
dc.contributor.authorModesto, Adriana
dc.contributor.authorVieira, Alexandre R.
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:42Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:42Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Çocuk Diş Hekimliği Ana Bilim Dalı
dc.descriptionWOS: 000429971300011
dc.descriptionPubMed ID: 29500156
dc.description.abstractObjective. The goal of the present work was to use dental conditions that have been independently associated with cleft lip and palate (CL/P) as a tool to identify a broader collection of individuals to be used for gene identification that lead to clefts. Study design. We studied 1573 DNA samples combining individuals that were born with CL/P or had tooth agenesis, supernumerary teeth, molar incisor hypomineralization, or dental caries with the goal to identify genetic associations. We tested 2 single-nucleotide polymorphisms that were located in the vicinity of regions suggested to contribute to supernumerary teeth. Overrepresentation of alleles were determined for combinations of individuals as well as for each individual phenotypic group with an alpha of.05. Results. We determined that the allele C of rs622260 was overrepresented in all individuals studied compared with a group of unrelated individuals who did not present any of the conditions described earlier. When subgroups were tested, associations were found for individuals with hypomineralization. Conclusions. Although we did not test this hypothesis directly in the present study, based on associations reported previously, we believe that CL/P is actually a syndrome of alterations of the dentition, and considering it that way may allow for the identification of genotype-phenotype correlations that may be useful for clinical care.
dc.identifier.citationKoruyucu, M., Kasımoğlu, Y., Seymen, F., Bayram, M., Patır Münevveroğlu, A., Ergöz, N. ... Vieira, A. (2018). Rethinking isolated cleft lip and palate as a syndrome. Oral Surgery Oral Medicine Oral Pathology Oral Radiology, 125(4), 307-312. https://dx.doi.org/10.1016/j.oooo.2018.01.007
dc.identifier.doi10.1016/j.oooo.2018.01.007
dc.identifier.endpage312
dc.identifier.issn2212-4403
dc.identifier.issn1528-395X
dc.identifier.issue4
dc.identifier.scopusqualityQ1
dc.identifier.startpage307
dc.identifier.urihttps://dx.doi.org/10.1016/j.oooo.2018.01.007
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2054
dc.identifier.volume125
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofOral Surgery Oral Medicine Oral Pathology Oral Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCleft Lip
dc.subjectCleft Palate
dc.subjectDental Anomalies
dc.subjectHMCN1 Protein Human
dc.subjectIGSF9 Protein Humanim
dc.subjectMunoglobulin
dc.subjectNerve Protein
dc.titleRethinking isolated cleft lip and palate as a syndrome
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Bayram, M..pdf
Boyut:
459.11 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Diş Hekimliği Fakültesi Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu