The relationship between zonulin and metabolic syndrome in renal transplant patients

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dc.authorid0000-0002-1824-9934
dc.authorid0000-0003-1185-9737
dc.authorid0000-0002-8351-4220
dc.authorid0000-0003-2350-6381
dc.authorid0000-0002-8662-5284
dc.authorid0000-0001-8036-8021
dc.contributor.authorCanbaloğlu Erkan, Gülbanu
dc.contributor.authorŞumnu, Abdullah
dc.contributor.authorErtuğrul, Gökhan
dc.contributor.authorÜlfer, Gözde
dc.contributor.authorÇakıcı, Çağrı
dc.contributor.authorAydın, Hüseyin Çağatay
dc.contributor.authorÜnal, Aydın
dc.date.accessioned2023-09-13T08:55:15Z
dc.date.available2023-09-13T08:55:15Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Organ Nakli Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractBackground: Levels of zonulin, a surrogate marker of intestinal permeability, are elevated in various disorders including insulin resistance, obesity, celiac disease, and inflammatory bowel disease. We aimed to elucidate the association of zonulin levels and metabolic syndrome (MS) in renal transplant recipients. Methods: Seventy-nine renal transplant recipients were enrolled. Diagnosis of MS was established employing the Adult Treatment Panel III (ATP III) criteria. Serum zonulin level was determined using the double antibody sandwich ELISA method. Results: MS was encountered in 37 (41.6%) of the 79 patients. Serum zonulin level was significantly higher in patients with MS compared to those without MS (p < 0.001). Serum zonulin level correlated with presence of MS (r: 739, p < 0.001), abdominal obesity (r: 514, p < 0.001), fasting glucose level (r: 361, p: 0.001), presence of fasting glucose/diabetes criterion of MS (r: 316, p: 0.005), presence of low HDL criterion of MS (r: 266, p: 0.018), and BMI (r: 527, p < 0.001). Conclusions: A Zonulin-mediated increase in intestinal permeability may play a role in the pathogenesis of metabolic syndrome. We propose that zonulin may be a suitable surrogate marker of MS in renal transplant recipients.
dc.description.sponsorshipTurkish Society of Nephrologyen_US
dc.identifier.citationCanbaloğlu Erkan, G., Şumnu, A., Ertuğrul, G., Ülfer, G., Çakıcı, Ç., Aydın, H. Ç. ... Ünal, A. (2023). The relationship between zonulin and metabolic syndrome in renal transplant patients. Clinical Laboratory, 69(1), 92-98. https://dx.doi.org/10.7754/Clin.Lab.2022.220341
dc.identifier.doi10.7754/Clin.Lab.2022.220341
dc.identifier.endpage98
dc.identifier.issn1433-6510
dc.identifier.issue1
dc.identifier.pmid36649519
dc.identifier.scopus2-s2.0-85146401504
dc.identifier.scopusqualityQ3
dc.identifier.startpage92
dc.identifier.urihttps://dx.doi.org/10.7754/Clin.Lab.2022.220341
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11418
dc.identifier.volume69
dc.identifier.wos000913693800001en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorCanbaloğlu Erkan, Gülbanu
dc.institutionauthorŞumnu, Abdullah
dc.institutionauthorErtuğrul, Gökhan
dc.institutionauthorÜlfer, Gözde
dc.institutionauthorÇakıcı, Çağrı
dc.institutionauthorAydın, Hüseyin Çağatay
dc.institutionauthorÜnal, Aydın
dc.language.isoen
dc.publisherVerlag Klinisches Labor GmbH
dc.relation.ispartofClinical Laboratoryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBody Mass Index
dc.subjectGlucose
dc.subjectKidney Transplantation
dc.subjectMetabolic Syndrome
dc.subjectZonulin
dc.titleThe relationship between zonulin and metabolic syndrome in renal transplant patients
dc.typeArticle

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