Clinical and pathologic features of primary membranous nephropathy in Turkey: A multicenter study by the Turkish Society of Nephrology Glomerular Diseases Working Group

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dc.authorid0000-0003-1185-9737
dc.contributor.authorYıldız, Abdulmecit
dc.contributor.authorUlu, Sena
dc.contributor.authorOruç, Ayşegül
dc.contributor.authorUçar, Ali Rıza
dc.contributor.authorÖztürk, Savaş
dc.contributor.authorAlagöz, Selma
dc.contributor.authorEren, Necmi
dc.contributor.authorKoçyiğit, İsmail
dc.contributor.authorKöksal Cevher, Simal
dc.contributor.authorHaras, Ali Burak
dc.contributor.authorŞumnu, Abdullah
dc.contributor.authorArınsoy, Turgay
dc.contributor.authorŞahin, Garip
dc.contributor.authorSüleymanlar, Gültekin
dc.contributor.authorÇavdar, Caner
dc.contributor.authorKumru Şahin, Gizem
dc.contributor.authorKurultak, İlhan
dc.contributor.authorÜnsal, Abdulkadir
dc.contributor.authorŞahin, Gülizar
dc.contributor.authorKazan, Sinan
dc.contributor.authorTatar, Erhan
dc.contributor.authorDikeç, Mehmet
dc.contributor.authorDursun, Belda
dc.contributor.authorSayarlıoğlu, Hayriye
dc.contributor.authorTürkmen, Kultigin
dc.contributor.authorArtan, Ayşe Serra
dc.contributor.authorAktaş, Nimet
dc.contributor.authorYılmaz, Zülfikar
dc.contributor.authorBehlül, Ahmet
dc.contributor.authorDheir, Hamad
dc.contributor.authorKutlay, Sim
dc.contributor.authorSeyahi, Nurhan
dc.date.accessioned2022-07-19T06:31:57Z
dc.date.available2022-07-19T06:31:57Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: We aimed to evaluate the features of primary membranous nephropathy (MNP) in Turkish people. Methods: This is a retrospective analysis of patients with biopsy-proven primary MNP. We obtained the data collected between 2009 and 2019 in the primary glomerulonephritis registry of the Turkish Society of Nephrology Glomerular Diseases Study Group (TSN-GOLD). Patients with a secondary cause for MNP were excluded. Clinical, demographic, laboratory, and histopathological findings were analyzed. Results: A total of 995 patients with primary MNP were included in the analyses. Males constituted the majority (58.8%). The mean age was 48.4 ± 13.9 years. The most common presentation was the presence of nephrotic syndrome (81.7%) and sub nephrotic proteinuria (10.3%). Microscopic hematuria was detected in one-third of patients. The median estimated glomerular filtration rate (eGFR) was 100.6 mL/min/1.73 m2 (IQR, 75.4–116.3), and median proteinuria was 6000 mg/d (IQR, 3656–9457). Serum C3 and C4 complement levels were decreased in 3.7 and 1.7% of patients, respectively. Twenty-four (2.4%) patients had glomerular crescents in their kidney biopsy samples. Basal membrane thickening was detected in 93.8% of cases under light microscopy. Mesangial proliferation and interstitial inflammation were evident in 32.8 and 55.9% of the patients, respectively. The most commonly detected depositions were IgG (93%), C3 complement (68.8%), and kappa and lambda immunoglobulin light chains (70%). Although renal functions were normal at presentation, vascular, interstitial, and glomerular findings were more prominent on biopsy in hypertensive patients. No significant effect of BMI on biopsy findings was observed. Conclusions: Despite some atypical findings, the main features of primary MNP in Turkey were similar to the published literature. This is the largest MNP study to date conducted in Turkish people.
dc.identifier.citationYıldız, A., Ulu, S., Oruç, A., Uçar, A. R., Öztürk, S., Alagöz, S. ... Seyahi, N. (2022). Clinical and pathologic features of primary membranous nephropathy in Turkey: A multicenter study by the Turkish Society of Nephrology Glomerular Diseases Working Group. Renal Failure, 44(1), 1048-1059. http://doi.org/10.1080/0886022X.2022.2079526
dc.identifier.doi10.1080/0886022X.2022.2079526
dc.identifier.endpage1059
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue1
dc.identifier.pmid35786180
dc.identifier.scopus2-s2.0-85133243986
dc.identifier.scopusqualityQ2
dc.identifier.startpage1048
dc.identifier.urihttp://doi.org/10.1080/0886022X.2022.2079526
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9584
dc.identifier.volume44
dc.identifier.wos000820567200001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞumnu, Abdullah
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectHistopathology
dc.subjectImmunofluorescence
dc.subjectKidney Biopsy
dc.subjectNephrotic Syndrome
dc.subjectPrimary Membranous Nephropathy
dc.subjectTurkey
dc.titleClinical and pathologic features of primary membranous nephropathy in Turkey: A multicenter study by the Turkish Society of Nephrology Glomerular Diseases Working Group
dc.typeArticle

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