Prognostic implications of baseline and new-onset fragmented qrs complex in patients undergoing transcatheter aortic valve implantation

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dc.contributor.authorHakgör, Aykun
dc.contributor.authorDursun, Atakan
dc.contributor.authorAkhundova, Aysel
dc.contributor.authorKenger, Melike Zeynep
dc.contributor.authorSavur, Ümeyir
dc.contributor.authorDerviş, Emir
dc.contributor.authorÇeleğen, Muhammed Furkan
dc.contributor.authorBoztosun, Bilal
dc.date.accessioned2025-10-27T08:41:32Z
dc.date.available2025-10-27T08:41:32Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractFragmented QRS complex (fQRS), which can be easily detected by electrocardiography (ECG), is an indicator of myocardial fibrosis and has adverse prognostic impact in cardiovascular diseases. The aim of this study was to investigate the effect of the presence of both pre-and post-operative fQRS on short-and long-term prognosis in patients undergoing transcatheter aortic valve implantation (TAVI) for severe aortic stenosis (AS). Data of 615 patients who underwent TAVI from different risk categories in a single-center were retrospectively screened and 289 patients were included after exclusion criteria. The presence of fQRS was recorded on pre-and postoperative ECGs and the effect of the fQRS on in-hospital and 2-year all-cause mortality was investigated. fQRS was detected in 85 (29.4%) patients before TAVI and also 24 (11.8%) patients had new-onset fQRS after TAVI. The presence of preop fQRS was found to be an independent predictor of in-hospital mortality. Postop fQRS, moderate or severe paravalvular aortic regurgitation and high systolic pulmonary artery pressure were associated with long-term mortality. In addition, patients with preop fQRS were more likely to need permanent pacemaker implantation after TAVI (14.1% vs. 2.9%). fQRS, which can be considered an indicator of subclinical left ventricular dysfunction due to myocardial fibrosis, is associated with decreased short-and long-term survival in patients undergoing TAVI. The presence of preop fQRS and postop new-onset fQRS is associated with a 3.8-and 3.2-fold increased cumulative mortality risk, respectively, at 24-month follow-up compared to patients without fQRS.
dc.identifier.citationHakgör, A., Dursun, A., Akhundova, A., Kenger, M. Z., Savur, Ü., Derviş, E. ... Boztosun, B. (2024). Prognostic implications of baseline and new-onset fragmented qrs complex in patients undergoing transcatheter aortic valve implantation. Eastern Journal of Medicine, 29(4), 478-486. http://dx.doi.org/10.5505/ejm.2024.01979
dc.identifier.doi10.5505/ejm.2024.01979
dc.identifier.endpage486
dc.identifier.issn1301-0883
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85207832608
dc.identifier.scopusqualityQ4
dc.identifier.startpage478
dc.identifier.urihttp://dx.doi.org/10.5505/ejm.2024.01979
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13145
dc.identifier.volume29
dc.indekslendigikaynakScopus
dc.institutionauthorHakgör, Aykun
dc.institutionauthorDursun, Atakan
dc.institutionauthorAkhundova, Aysel
dc.institutionauthorKenger, Melike Zeynep
dc.institutionauthorSavur, Ümeyir
dc.institutionauthorDerviş, Emir
dc.institutionauthorBoztosun, Bilal
dc.institutionauthorid0000-0001-8252-0373
dc.institutionauthorid0000-0001-5074-5340
dc.institutionauthorid0000-0002-4066-6822
dc.institutionauthorid0009-0008-2688-7232
dc.institutionauthorid0000-0003-1320-9033
dc.institutionauthorid0000-0003-3221-2166
dc.institutionauthorid0000-0002-4951-6716
dc.language.isoen
dc.relation.ispartofEastern Journal of Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAortic Stenosis
dc.subjectElectrocardiogram
dc.subjectFragmented QRS Complex
dc.subjectLong-Term Outcomes
dc.subjectTranscatheter Aortic Valve Implantation
dc.titlePrognostic implications of baseline and new-onset fragmented qrs complex in patients undergoing transcatheter aortic valve implantation
dc.typeArticle

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