Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat multiple sclerosis model

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dc.contributor.authorBayıroğlu, Ayşenur Feyza
dc.contributor.authorAcar, Gözde
dc.contributor.authorGülbahçe Mutlu, Elif
dc.contributor.authorBaltacı, Saltuk Buğra
dc.contributor.authorMoğulkoç, Rasim
dc.contributor.authorBaltacı, Abdulkerim Kasım
dc.date.accessioned2025-08-28T12:24:40Z
dc.date.available2025-08-28T12:24:40Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractThe aim of this study was to investigate the effects of dietary zinc status on spinal cord tissue damage and ZnT3, IL-6 gene expressions in a cuprizone-induced rat Multiple Sclerosis (MS) model. The study was carried out on 46 adult male rats of the genus Wistar. The animals used in the study were divided into 5 groups (G) (Control 6, other groups 10). G1, Control. G2, Sham-MS: Carboxy-methyl-cellulose (KMS) solution in which Cuprizon was dissolved was given to rats by gavage daily for 8 weeks at the rate of 1 % of daily feed consumption. MS was formed by giving 1 % of the daily feed consumption cuprizon in KMS solution by gavage to the animals in G3, 4 and 5 for 8 weeks. G4 was fed with a zinc deficient (50 µg/kg zinc) diet. G5 was given intraperitoneal (ip) zinc sulfate (5 mg/kg/day) supplementation. MS formation in animals was determined by Rotarod tests and Myelin Basic Protein (MBP) gene expression analysis. ZNT3 and IL-6 gene expression levels in spinal cord tissue samples of animals by Real-Time-PCR method; MDA and GSH levels were determined by ELISA method. The highest spinal cord MDA and IL-6 levels were obtained in G3 and G4 (P<0.05). Zinc supplementation in G5 prevented the increase in the mentioned parameters and turned them into control values (P<0.05). The spinal cord GSH and ZnT3 levels of G3 and G4 were lower than all other groups (P<0.05). Zinc supplementation prevented suppression in the same parameters in G5 and reached the control values (P<0.05). The findings of the current study suggest that zinc supplementation in addition to treatment for MS may be beneficial in reducing the severity of the disease.
dc.description.sponsorshipScientific Research Projects Coor-dinatorship of Selcuk University
dc.identifier.citationBayıroğlu, A. F., Acar, G., Gülbahçe Mutlu, E., Baltacı, S. B., Moğulkoç, R. ve Baltacı, A. K. (2024). Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat multiple sclerosis model. Journal of Trace Elements in Medicine and Biology, 86. http://dx.doi.org/10.1016/j.jtemb.2024.127540
dc.identifier.doi10.1016/j.jtemb.2024.127540
dc.identifier.issn0946-672X
dc.identifier.issn1878-3252
dc.identifier.pmid39383661
dc.identifier.scopus2-s2.0-85205693594
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.1016/j.jtemb.2024.127540
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13038
dc.identifier.volume86
dc.identifier.wosWOS:001334883600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBaltacı, Saltuk Buğra
dc.language.isoen
dc.relation.ecinfo:eu-repo/grantAgreement/EC/FP7/21202016
dc.relation.ispartofJournal of Trace Elements in Medicine and Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectCuprizone
dc.subjectIL-6
dc.subjectMultiple Sclerosis
dc.subjectOxidative Stress
dc.subjectSpinal Cord
dc.subjectZinc
dc.subjectZnT3
dc.titleDietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat multiple sclerosis model
dc.typeArticle

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