Can tissue factor, a multifactorial molecule of the hemostasis, be used as a biomarker for thrombosis, inflammation and cancer?

Basit Öğe Kaydı
dc.contributor.authorEmekli, Nesrin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:12Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:12Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractTissue factor (TF) is a transmembrane protein found in many tissues and is active in various biological reactions. It is a member of the cytokine receptor superfam-ily and is referred to as CD 142 because of this feature. TF is also known as Factor III in the coagulation system and binds FVII/VIIa. The TF and FVIIa complex has both procoagulant and signaling activities. It functions in many biological processes, including hemostasis, thrombosis, inflammation and cancer. TF is essential for haemostasis but increased TF expression within atherosclerotic plaques and TF positive microparticles were detected in thrombotic conditions. TF increases inflammation by enhancing intravascular fibrin deposition and activates protease-activated receptors (PARs). TF and FVIIa complex also contribute to tumor growth by activating PAR2. Recent retrospective studies have shown that TF positive microparticles increase in the plasma of cancer patients. Therefore TF may be suggested to be used as a biomarker. However further studies are required to reveal the availability of TF as a biomarker to identify cancer and risk of thromosis and inflammation.
dc.identifier.citationEmekli, N. (2017). Can tissue factor, a multifactorial molecule of the hemostasis, be used as a biomarker for thrombosis, inflammation and cancer? Acta Pharmaceutica Sciencia, 55(3), 93-104. https://dx.doi.org/10.23893/1307-2080.APS.05521
dc.identifier.doi10.23893/1307-2080.APS.05521
dc.identifier.endpage104
dc.identifier.issn1307-2080
dc.identifier.issue3
dc.identifier.scopusqualityQ4
dc.identifier.startpage93
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1094
dc.identifier.urihttps://dx.doi.org/10.23893/1307-2080.APS.05521
dc.identifier.volume55
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniversity of Istanbul
dc.relation.ispartofActa Pharmaceutica Scienciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCancer
dc.subjectHemostasis
dc.subjectInflammation
dc.subjectThrombosis
dc.subjectTissue Factor
dc.titleCan tissue factor, a multifactorial molecule of the hemostasis, be used as a biomarker for thrombosis, inflammation and cancer?
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
Ä°sim:
emekli-nesrin(2017).pdf
Boyut:
233.2 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
Ä°ndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu