The role of makorin ring finger protein-3, kisspeptin, and neurokinin B in the physiology of minipuberty

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dc.authorid0000-0003-2350-6381
dc.authorid0000-0002-0675-1839
dc.authorid0000-0002-8662-5284
dc.authorid0000-0002-8968-4079
dc.authorid0000-0002-1044-6888
dc.contributor.authorAtay, Enver
dc.contributor.authorKılınç, Suna
dc.contributor.authorÜlfer, Gözde
dc.contributor.authorYiğitbaşı, Türkan
dc.contributor.authorÇakıcı, Çağrı
dc.contributor.authorTuran, Murat
dc.contributor.authorCeran, Ömer
dc.contributor.authorAtay, Zeynep
dc.date.accessioned2021-04-01T05:48:35Z
dc.date.available2021-04-01T05:48:35Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractBackground: There is no data regarding the interrelationships of circulating Makorin Ring Finger Protein-3 (MKRN3), Kisspeptin (KISS1), and Neurokinin B (NKB) concentrations during minipuberty in humans.Objective: To determine temporal changes in circulating concentrations of MKRN3, KISS1, NKB, and gonadotropins and investigate interrelationships between them in healthy full-term (FT) and preterm (PT) infants during minipuberty period.Methods: A prospective study of 6-month follow-up performed. Eighty-seven healthy newborns, 48 FT (19 boys/29 girls), and 39 PT (21 boys/18 girls) (gestational age 31-37 weeks), were included. Blood samples were taken at 7 days (D7), 2 months (M2), and 6 months (M6) of age. Serum MKRN3, KISS1, NKB, LH, FSH, total testosterone (TT), and estradiol (E2) concentrations were measured.Results: Seventy infants completed the study. MKRN3, KISS1, and NKB concentrations were similar in FT girls and boys. PT boys and girls also had similar concentrations of MKRN3, KISS1, and NKB. FT babies had significantly higher NKB concentrations than PT babies at D7, M2, and M6. MKRN3 and KISS1 concentrations do not differ between FT and PT babies. A strong positive correlation was found between MKRN3 and KISS1 at each time point and in all groups. FSH, LH, TT/E2 concentrations decrease while those of MKRN3 and KISS1 have a trend to increase toward the end of minipuberty. No correlation was detected between gonadotropins and MKRN3, KISS1, NKB concentrations.Conclusion: Strong positive correlation demonstrated between KISS1 and MKRN3 suggests that interrelationship between molecules controlling minipuberty is not similar to those at puberty.
dc.description.sponsorshipIstanbul Medipol University Scientific Research Support programen_US
dc.identifier.citationAtay, E., Kılınç, S., Ülfer, G., Yiğitbaşı, T., Çakıcı, Ç., Turan, M. ... Atay, Z. (2021). The role of makorin ring finger protein-3, kisspeptin, and neurokinin B in the physiology of minipuberty. Journal of Pediatric Endocrinology and Metabolism, 34(3), 325-332. https://dx.doi.org/10.1515/jpem-2020-0331
dc.identifier.doi10.1515/jpem-2020-0331
dc.identifier.endpage332
dc.identifier.issn0334-018X
dc.identifier.issn2191-0251
dc.identifier.issue3
dc.identifier.scopusqualityQ3
dc.identifier.startpage325
dc.identifier.urihttps://dx.doi.org/10.1515/jpem-2020-0331
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6662
dc.identifier.volume34
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWalter de Gruyter GmbH
dc.relation.ispartofJournal of Pediatric Endocrinology and Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectKisspeptin (KISS1)
dc.subjectMakorin Ring Finger Protein-3 (MKRN3)
dc.subjectMinipuberty
dc.subjectNeurokinin B (NKB)
dc.titleThe role of makorin ring finger protein-3, kisspeptin, and neurokinin B in the physiology of minipuberty
dc.typeArticle

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