Development of a chemogenetic approach to manipulate intracellular pH

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dc.authorid0000-0003-4625-106X
dc.authorid0000-0003-2033-860X
dc.authorid0000-0001-9037-5217
dc.authorid0000-0002-6393-1465
dc.authorid0000-0003-0352-1947
dc.authorid0000-0002-9373-0808
dc.contributor.authorZaki, Asal Ghaffari
dc.contributor.authorMiri, Seyed Mohammad
dc.contributor.authorÇimen, Şeyma
dc.contributor.authorAkgül Çağlar, Tuba
dc.contributor.authorYiğit, Esra Nur
dc.contributor.authorAydın, Mehmet S.
dc.contributor.authorÖztürk, Gürkan
dc.contributor.authorEroğlu, Emrah
dc.date.accessioned2023-07-05T07:05:53Z
dc.date.available2023-07-05T07:05:53Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractChemogenetic Operation of iNTRacellular prOton Levels(pH-Control)is a novel substrate-based enzymatic method that enables precise spatiotemporalcontrol of ultralocal acidification in cultured cell lines and primaryneurons. The genetically encoded biosensor SypHer3s showed that pH-Controleffectively acidifies cytosolic, mitochondrial, and nuclear pH exclusivelyin the presence of beta-chloro-d-alanine in living cellsin a concentration-dependent manner. The pH-Control approach is promisingfor investigating the ultralocal pH imbalance associated with manydiseases.
dc.description.sponsorshipCE254SWXHI ; NN254SWPZX ; CP254SWT2Ren_US
dc.identifier.citationZaki, A. G., Miri, S. M., Çimen, Ş., Akgül Çağlar, T., Yiğit, E. N., Aydın, M. Ş. ... Eroğlu, E. (2023). Development of a chemogenetic approach to manipulate intracellular pH. Journal of the American Chemical Society, 145(22), 11899-11902. https://dx.doi.org/10.1021/jacs.3c00703
dc.identifier.doi10.1021/jacs.3c00703
dc.identifier.endpage11902
dc.identifier.issn0002-7863
dc.identifier.issn1520-5126
dc.identifier.issue22
dc.identifier.pmid37222194
dc.identifier.scopus2-s2.0-85162029373
dc.identifier.scopusqualityQ1
dc.identifier.startpage11899
dc.identifier.urihttps://dx.doi.org/10.1021/jacs.3c00703
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11143
dc.identifier.volume145
dc.identifier.wos001004152400001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorZaki, Asal Ghaffari
dc.institutionauthorMiri, Seyed Mohammad
dc.institutionauthorÇimen, Şeyma
dc.institutionauthorAkgül Çağlar, Tuba
dc.institutionauthorYiğit, Esra Nur
dc.institutionauthorAydın, Mehmet S.
dc.institutionauthorÖztürk, Gürkan
dc.institutionauthorEroğlu, Emrah
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.relation.ispartofJournal of the American Chemical Societyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectChemogenetic Approach
dc.subjectIntracellular pH
dc.subjectDevelopment
dc.titleDevelopment of a chemogenetic approach to manipulate intracellular pH
dc.typeArticle

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