Comparison of transepithelial corneal collagen crosslinking with epithelium-off crosslinking in progressive keratoconus

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dc.authorid0000-0002-0972-3833
dc.contributor.authorKoçak, İbrahim
dc.contributor.authorAydın, Ali
dc.contributor.authorKaya, Faruk
dc.contributor.authorKoç, Hacı
dc.date.accessioned2020-06-23T06:41:31Z
dc.date.available2020-06-23T06:41:31Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı
dc.description.abstractPurpose. - To evaluate the safety and efficacy of transepithelial corneal collagen crosslinking (TE-CXL) as compared to epithelium-off crosslinking (epi-off CXL) in progressive keratoconus. Methods. - Records of keratoconus patients treated with TE-CXL or epi-off CXL were reviewed retrospectively. Patients were included if they had at least 12 months follow-up. Pre- and postoperative measurements of visual acuity, refractive errors, keratometry, corneal topography and pachymetry were assessed and compared. Results. - There was no statistically significant difference between two groups at baseline in terms of demographic, refractive and corneal parameters. Mean maximum cone apex curvature (apical K) increased from 51.62 +/- 5. Eighty-four diopters (D) to 53.70 +/- 5.49 D in the TE-CXL group (n = 17), and decreased from 52.02 +/- 4.07 D to 51.22 +/- 3.51 in the epi-off CXL group (n = 19) at the end of the follow-up period. The difference between two groups was statistically significant (P = 0.0002). An increase of >= 1D in apical K was observed in two of 19 eyes (11%) in the epi-off CXL group, and 11 of 17 eyes (65%) in TE-CXL group at the last follow-up visit, compared to baseline (P < 0.0001). Fourteen patients in the epi-off CXL group exhibited corneal edema that resolved without haze with topical corticosteroid treatment by 4 months. No postoperative corneal edema was observed in TE-CXL group. Conclusions. - Although it is safe and well tolerated, TE-CXL does not effectively halt the progression of keratoconus. Epi-off CXL appears to be effective in stopping progression and even improves corneal parameters. (C) 2014 Elsevier Masson SAS. All rights reserved.
dc.identifier.citationKoçak, İ., Aydın, A., Kaya, F. ve Koç, H. (2014). Comparison of transepithelial corneal collagen crosslinking with epithelium-off crosslinking in progressive keratoconus. Journal Francais D Ophtalmologie, 37(5), 371-376. https://dx.doi.org/10.1016/j.jfo.2013.11.012
dc.identifier.doi10.1016/j.jfo.2013.11.012
dc.identifier.endpage376
dc.identifier.issn0181-5512
dc.identifier.issn1773-0597
dc.identifier.issue5
dc.identifier.scopusqualityQ3
dc.identifier.startpage371
dc.identifier.urihttps://dx.doi.org/10.1016/j.jfo.2013.11.012
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5285
dc.identifier.volume37
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMasson Editeur
dc.relation.ispartofJournal Francais D Ophtalmologieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectKeratoconus
dc.subjectCorneal Collagen Crosslinking
dc.subjectTransepithelial
dc.titleComparison of transepithelial corneal collagen crosslinking with epithelium-off crosslinking in progressive keratoconus
dc.typeArticle

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