Longitudinal metabolomics analysis reveals the acute effect of cysteine and NAC included in the combined metabolic activators

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dc.authorid0000-0003-0352-1947
dc.contributor.authorYang, Hong
dc.contributor.authorLi, Xiangyu
dc.contributor.authorJin, Han
dc.contributor.authorTürkez, Hasan
dc.contributor.authorÖztürk, Gürkan
dc.contributor.authorDoğanay, Hamdi Levent
dc.date.accessioned2023-06-09T12:38:27Z
dc.date.available2023-06-09T12:38:27Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.description.abstractGrowing evidence suggests that the depletion of plasma NAD+ and glutathione (GSH) may play an important role in the development of metabolic disorders. The administration of Combined Metabolic Activators (CMA), consisting of GSH and NAD+ precursors, has been explored as a promising therapeutic strategy to target multiple altered pathways associated with the pathogenesis of the diseases. Although studies have examined the therapeutic effect of CMA that contains N-acetyl-L-cysteine (NAC) as a metabolic activator, a system-wide comparison of the metabolic response to the administration of CMA with NAC and cysteine remains lacking. In this placebo-controlled study, we studied the acute effect of the CMA administration with different metabolic activators, including NAC or cysteine with/without nicotinamide or flush free niacin, and performed longitudinal untargeted-metabolomics profiling of plasma obtained from 70 well-characterized healthy volunteers. The time-series metabolomics data revealed the metabolic pathways affected after the administration of CMAs showed high similarity between CMA containing nicotinamide and NAC or cysteine as metabolic activators. Our analysis also showed that CMA with cysteine is well-tolerated and safe in healthy individuals throughout the study. Last, our study systematically provided insights into a complex and dynamics landscape involved in amino acid, lipid and nicotinamide metabolism, reflecting the metabolic responses to CMA administration containing different metabolic activators.
dc.description.sponsorshipPoLiMeR Innovative Training Network ; SNIC ; ScandiBio Therapeutics ; U.S. Food and Drug Administration ; H2020 Marie Skłodowska-Curie Actions ; National Arts Council - Singapore ; Knut och Alice Wallenbergs Stiftelse ; Chinese Medical Association ; Horizon 2020en_US
dc.identifier.citationYang, H., Li, X., Jin, H., Türkez, H., Öztürk, G. ve Doğanay, H. L. (2023). Longitudinal metabolomics analysis reveals the acute effect of cysteine and NAC included in the combined metabolic activators. Free Radical Biology and Medicine, 204, 347-358. https://doi.org/10.1016/j.freeradbiomed.2023.05.013
dc.identifier.doi10.1016/j.freeradbiomed.2023.05.013
dc.identifier.endpage358
dc.identifier.issn0891-5849
dc.identifier.issn1873-4596
dc.identifier.pmid37245532
dc.identifier.scopus8915849
dc.identifier.scopusqualityQ1
dc.identifier.startpage347
dc.identifier.urihttps://doi.org/10.1016/j.freeradbiomed.2023.05.013
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11060
dc.identifier.volume204
dc.identifier.wos001014625400001*
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖztürk, Gürkan
dc.language.isoen
dc.publisherElsevier Inc.
dc.relation.ispartofFree Radical Biology and Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMetabolomics
dc.subjectCombined Metabolic Activators
dc.subjectN-Acetyl-L-Cysteine
dc.subjectCysteine
dc.subjectNicotinamide
dc.subjectNiacin
dc.titleLongitudinal metabolomics analysis reveals the acute effect of cysteine and NAC included in the combined metabolic activators
dc.typeArticle

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