Influence of periodontal inflammation on tryptophan-kynurenine metabolism: A cross-sectional study

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dc.contributor.authorKurgan, Şivge
dc.contributor.authorÖnder, Canan
dc.contributor.authorBalcı, Nur
dc.contributor.authorAkdoğan, Nihan
dc.contributor.authorAltıngöz, Sema Merve
dc.contributor.authorSerdar, Muhittin Abdulkadir
dc.contributor.authorGünhan, Meral
dc.date.accessioned2022-11-23T10:36:32Z
dc.date.available2022-11-23T10:36:32Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalı
dc.description.abstractObjectives Kynurenine pathway (KP) is the primary way of degrading tryptophan (TRP) and generates several bioactive metabolites (such as kynurenine (KYN), kynurenic acid (KYNA), 3-hydroxykynurenine (3OHKYN)) to regulate biological processes that include host-microbiome signaling and immune cell response. This study is aimed to determine the relationship between periodontal inflammation and tryptophan-kynurenine metabolism and identify their association with periodontal clinical parameters. Materials and methods Saliva and serum samples were collected from 20 stage III, grade B generalized periodontitis patients, and 20 periodontally healthy control individuals. Samples were analyzed for IL-6, KYN, TRP, KYN/TRP ratio, KYNA, 3OHKYN, picolinic acid (PA), and quinolinic acid (QA) by liquid chromatography-mass spectrometry. Clinical periodontal parameters (plaque index (PI), probing pocket depth (PPD), gingival recession (GR), clinical attachment loss (CAL), and bleeding on probing (BOP)) were recorded. Results Clinical parameters were significantly higher in the periodontitis group (p < 0.001). Salivary IL-6, TRP, KYN, KYNA, PA, and QA levels were significantly higher and KYN/TRP ratio was significantly lower in periodontitis group than control group (p < 0.05). Serum KYN, KYN/TRP ratio and PA levels were significantly higher in periodontitis group than control group (p < 0.05). PPD, BOP, PI, and CAL had significantly positive correlations with salivary IL-6, TRP, PA, QA, and serum KYN and significantly negative correlations with salivary KYN/TRP ratio. Conclusions Our results suggest that periodontal inflammation plays a role in local and systemic tryptophan-kynurenine metabolism.
dc.description.sponsorshipAnkara University Department of Periodontology ; Istanbul Medipol University Department of Periodontologyen_US
dc.identifier.citationKurgan, Ş., Önder, C., Balcı, N., Akdoğan, N., Altıngöz, S. M., Serdar, M. A. ... Günhan, M. (2022). Influence of periodontal inflammation on tryptophan-kynurenine metabolism: A cross-sectional study. Clinical Oral Investigations, 26(9), 5721-5732. https://doi.org/10.1007/s00784-022-04528-4
dc.identifier.doi10.1007/s00784-022-04528-4
dc.identifier.endpage5732
dc.identifier.issn1432-6981
dc.identifier.issn1436-3771
dc.identifier.issue9
dc.identifier.pmid35588020
dc.identifier.scopus2-s2.0-85130493639
dc.identifier.scopusqualityQ1
dc.identifier.startpage5721
dc.identifier.urihttps://doi.org/10.1007/s00784-022-04528-4
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10017
dc.identifier.volume26
dc.identifier.wos000798204200001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBalcı, Nur
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofClinical Oral Investigationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectKynurenine Pathway
dc.subjectPeriodontitis
dc.subjectTryptophan
dc.titleInfluence of periodontal inflammation on tryptophan-kynurenine metabolism: A cross-sectional study
dc.typeArticle

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