Annexin levels in gcf determine the imbalance of periodontal inflammatory regulation

Basit Öğe Kaydı
dc.contributor.authorYılmaz, Melis
dc.contributor.authorBal, İpek
dc.contributor.authorHanlı, Sena
dc.contributor.authorTürkmen, Emrah
dc.contributor.authorBalcı, Nur
dc.contributor.authorUslu Toygar, Hilal
dc.date.accessioned2025-11-18T08:56:29Z
dc.date.available2025-11-18T08:56:29Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalı
dc.description.abstractObjective: Annexin-1 (ANXA1), a member of the annexin family, plays a role in the resolution of inflammation and the regulation of anti-inflammatory responses, while annexin-2 (ANXA2) is involved in the initiation of the inflammatory responses. The aim of this study was to determine the effects of annexin family (ANXA1 and ANXA2) in periodontal disease. Methods: Healthy participants (n:25) and stage III, grade B periodontitis (n:25) patients enrolled for this study. Clinical periodontal parameters and the periodontal inflamed surface area (PISA) levels were noted. Serum, saliva, and gingival crevicular fluid (GCF) samples were collected to measure the ANXA1, ANXA2 and IL-1β levels. Results: Salivary and serum concentrations of ANXA1 was significantly lower in the periodontitis group than in the control group (respectively, p = 0.0177 and p = < 0.0001). Periodontitis patients demonstrated higher serum ANXA2 and IL-1β concentrations compared to controls (respectively, p = 0.0002 and p = 0.0017). As an inflammatory index; saliva, serum and GCF ANXA1/ANXA2 ratio were significantly lower in the periodontitis group compared to healthy controls. Conclusions: The data suggest that periodontitis is associated with a disruption of the balance between pro-inflammatory mechanisms (ANXA2 and IL-1beta) and inflammation resolution (ANXA1), in parallel with PISA levels. Clinical Trial Registration: ClinicalTrials.gov NCT06554756 (15/08/2024).
dc.identifier.citationYılmaz, M., Bal, İ., Hanlı, S., Türkmen, E., Balcı, N. ve Uslu Toygar, H. (2024). Annexin levels in gcf determine the imbalance of periodontal inflammatory regulation. Scientific Reports, 14(1). http://dx.doi.org/10.1038/s41598-024-80418-x
dc.identifier.doi10.1038/s41598-024-80418-x
dc.identifier.issn2045-2322
dc.identifier.issue1
dc.identifier.pmid39572681
dc.identifier.scopus2-s2.0-85209724183
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.1038/s41598-024-80418-x
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13220
dc.identifier.volume14
dc.identifier.wosWOS:001361610900008
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmaz, Melis
dc.institutionauthorBal, İpek
dc.institutionauthorHanlı, Sena
dc.institutionauthorTürkmen, Emrah
dc.institutionauthorBalcı, Nur
dc.institutionauthorUslu Toygar, Hilal
dc.institutionauthorid0000-0001-5166-2109
dc.institutionauthorid0000-0001-7986-7085
dc.institutionauthorid0000-0001-7409-1484
dc.language.isoen
dc.relation.ispartofScientific Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAnnexin
dc.subjectCytokine
dc.subjectPeriodontitis
dc.titleAnnexin levels in gcf determine the imbalance of periodontal inflammatory regulation
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Yılmaz-Melis-2024.pdf
Boyut:
2.05 MB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Diş Hekimliği Fakültesi Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu