Resveratrol can prevent CCl4-induced liver injury by inhibiting notch signaling pathway

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dc.authorid0000-0003-2143-5268
dc.contributor.authorTanrıverdi, Gamze
dc.contributor.authorKaya Dağiştanlı, Fatma
dc.contributor.authorAyla, Şule
dc.contributor.authorDemirci, Sibel
dc.contributor.authorEser, Mediha
dc.contributor.authorÜnal, Zehra Seda
dc.contributor.authorCengiz, Müjgan
dc.contributor.authorOktar, Hüseyin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:12Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:12Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.descriptionWOS: 000376284000007
dc.descriptionPubMed ID: 26742567
dc.description.abstractWe investigated whether Notch signaling was increased in an experimental liver fibrosis model and examined the effects of resveratrol on Notch expression. Rats were divided into four groups: the control group, injected with physiological saline; the CCl4 group; the CCl4 plus resveratrol group; and the resveratrol group. After treatment, immunostaining was performed to detect Notch1, Notch3, Notch4, transforming growth factor (TGF)-beta, alpha-smooth muscle actin (SMA), glial fibrillary acidic protein (GFAP), and proliferating cell nuclear antigen (PCNA), and TUNEL assays were performed to evaluate apoptosis. Sirius red staining was used to detect fibrosis. Samples were also biochemically evaluated for glutathione (GSH), glutathione peroxidase (GPx), catalase (CAT), lipid peroxidation, and protein oxidation. GSH, GPx, and catalase activities were significantly decreased (p < 0.001) in the CCl4 group. Distinct collagen accumulation was detected around the central vein and portal areas, and numbers of Notch1-, Notch3-, and Notch4-positive cells were significantly increased (p < 0.001) in fibrotic areas in the CCl4 group. Increased expression of Notch proteins in fibrotic areas may support the role of Notch in mediating signaling associated with liver fibrosis through activation of hepatic stellate and progenitor cells. In contrast, resveratrol prevented liver fibrosis by decreasing lipid peroxidation and may be effective for inhibiting Notch signaling.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul University [UDP-3556]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Coordination Unit of Istanbul University, project number UDP-3556. The authors thank Azize Gumusyazici and Ercument Boztas, technicians in the electron microscopy laboratory at Istanbul University, Cerrahpasa Medical Faculty.en_US
dc.identifier.citationTanrıverdi, G., Kaya Dağiştanlı, F., Ayla, Ş., Demirci, S., Eser, M., Ünal, Z. S. ... Oktar, H. (2016). Resveratrol can prevent CCl4-induced liver injury by inhibiting notch signaling pathway. Histology And Histopathology, 31(7), 769-784. https://dx.doi.org/10.14670/HH-11-720
dc.identifier.doi10.14670/HH-11-720
dc.identifier.endpage784
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.issue7
dc.identifier.scopusqualityQ2
dc.identifier.startpage769
dc.identifier.urihttps://dx.doi.org/10.14670/HH-11-720
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2617
dc.identifier.volume31
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherF Hernandez
dc.relation.ispartofHistology And Histopathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLiver Fibrosis
dc.subjectNotch Signaling
dc.subjectResveratrol
dc.subjectLiver Regeneration
dc.subjectHepatotoxicity
dc.titleResveratrol can prevent CCl4-induced liver injury by inhibiting notch signaling pathway
dc.typeArticle

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