The importance of topical metronidazole in the treatment of acute anal fissure: A double-blind study controlled for prospective randomization

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dc.authorid0000-0002-4481-2161
dc.contributor.authorMert, Tuba
dc.date.accessioned2023-02-07T12:55:15Z
dc.date.available2023-02-07T12:55:15Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.description.abstractPurpose: Acute anal fissure, a disease characterized by severe pain in the anorectal area, reduces quality of life and becomes chronic absent appropriate treatment. More recently, anaerobic infections have been noted as contributive to etiopathogenesis. This study investigates topical metronidazole's effect in the treatment of acute anal fissure. Methods: Our prospective randomized controlled double-blind study included 2 groups of 100 patients older than 18 years from our General Surgery Clinic with anal fissure complaints for less than 8 weeks. Topical diltiazem treatment was started in group 1, and topical diltiazem and metronidazole treatment in group 2. Pain levels were evaluated by the visual analogue scale (VAS) score, and recovery status was evaluated by physical examination findings ab initio and at the 1st, 4th, and 6th weeks. VAS score levels, demographic, clinical, and recovery status were then compared. Results: There was no difference between the groups as to age, sex, pain on defecation, bleeding, constipation, and duration of pain, bleeding and constipation (P>0.05). From week 1, fissure epithelialization and healing rates were higher in group 2 (P<0.001); group 2 VAS score levels were lower than in group 1 (P<0.001) and achieved by group 1 only in week 4 (P=0.073). Conclusion: Adding topical metronidazole to treatment reduces the duration and severity of pain, shortens healing time, and increases the healing rate.
dc.identifier.citationMert, T. (2023). The importance of topical metronidazole in the treatment of acute anal fissure: A double-blind study controlled for prospective randomization. Annals of Coloproctology, 39(2), 131-138. https://dx.doi.org/10.3393/ac.2021.00675.0096
dc.identifier.doi10.3393/ac.2021.00675.0096
dc.identifier.endpage138
dc.identifier.issn2287-9714
dc.identifier.issn2287-9722
dc.identifier.issue2
dc.identifier.pmid35038820
dc.identifier.scopus2-s2.0-85161532659
dc.identifier.scopusqualityQ2
dc.identifier.startpage131
dc.identifier.urihttps://dx.doi.org/10.3393/ac.2021.00675.0096
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10404
dc.identifier.volume39
dc.identifier.wos000983053200005en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMert, Tuba
dc.language.isoen
dc.publisherSeoul: Korean Society of Coloproctology
dc.relation.ispartofAnnals of Coloproctologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectAcute Anal Fissure
dc.subjectAnti-Bacterial Agents
dc.subjectDiltiazem
dc.subjectMetronidazole
dc.subjectTopical Therapy
dc.titleThe importance of topical metronidazole in the treatment of acute anal fissure: A double-blind study controlled for prospective randomization
dc.typeArticle

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