Anti-inflammatory and hypoglycemic activities of alpha-pinene

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dc.authorid0000-0002-8084-7855
dc.contributor.authorÖzbek, Hanefi
dc.contributor.authorYılmaz, Betül Sever
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:13Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:13Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractThe aim of this study is to investigate the anti-inflammatory and hypoglycemic activities of alpha-pinene, and to find the median lethal dose (LD50) level in mice. Lethal dose levels of alpha-pinene were investigated using a probit analysis method. For the anti-inflammatory activity measurement seven different groups were established and alpha-pinene was administered in four different doses: 0.05, 0.10, 0.25 and 0.50 mL/kg. For the evaluation of hypoglycemic activity six different groups, consisting of diabetic and healthy mice, were established. The strongest anti-inflammatory activity of alpha-pinene was observed with a 0.50 mL/kg dosage. The median effective dose (ED50) value of alpha-pinene was found to be 0.039 mL/kg. In diabetic mice ?-pinene showed significant levels of hypoglycemic activity at the 2nd and 24th hours. LD50 level of ?-pinene was determined to be 2.076 mL/kg. As a result, we conclude that alpha-pinene is a molecule that displays hypoglycemic and anti-inflammatory activities.
dc.identifier.citationÖzbek, H. ve Yılmaz, B. S. (2017). Anti-inflammatory and hypoglycemic activities of alpha-pinene. Acta Pharmaceutica Sciencia, 55(4), 7-14. https://dx.doi.org/10.23893/1307-2080.APS.05522
dc.identifier.doi10.23893/1307-2080.APS.05522
dc.identifier.endpage14
dc.identifier.issn1307-2080
dc.identifier.issue4
dc.identifier.scopusqualityQ4
dc.identifier.startpage7
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1098
dc.identifier.urihttps://dx.doi.org/10.23893/1307-2080.APS.05522
dc.identifier.volume55
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniversity of Istanbul
dc.relation.ispartofActa Pharmaceutica Scienciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlpha-Pinene
dc.subjectAnti-Inflammatory Activity
dc.subjectHypoglycemic Activity
dc.subjectMice
dc.subjectRats
dc.titleAnti-inflammatory and hypoglycemic activities of alpha-pinene
dc.typeArticle

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