Effect of heparin on inflammation: An animal model of tracheal stents

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dc.contributor.authorBiçer, Yusuf Özgür
dc.contributor.authorKöybaşı, Serap
dc.contributor.authorSüslü, Ahmet Emre
dc.contributor.authorKükner, Aysel
dc.contributor.authorTezcan, Erkan
dc.contributor.authorUlaş, Nilüfer
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:38Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:38Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.descriptionWOS: 000341100500004
dc.descriptionPubMed ID: 24648297
dc.description.abstractObjectives/Hypothesis: The objective of this study was to investigate the effect of systemic heparin on tracheal and wound healing. Study Design: An animal experiment using a tracheal stent model. Methods: Twenty Wistar albino rats were divided into two groups; a heparin group (n=10) that received 210 U/kg/d heparin sodium, and a saline group (n=10) that received 0.1 mL of 9% NaCl. Stents of 1 cm in length made of 8F feeding tube were placed into the tracheas of rats in both groups and stayed in place for 10 days. Ten days after removal of the stents, the rats were sacrificed and the tracheas were harvested. Histological evaluations of the tracheas were performed with respect to inflammatory parameters. Results: We observed significantly milder inflammation in the heparin group compared to the saline group in terms of inflammatory cell count, fibroblastic proliferation, edema, and vascularity at the site where the tracheal incision was made (P<.05). Inflammation tended to be of a lesser extent in the stent site in the heparin group (P>.05). Conclusions: We could demonstrate that heparin does inhibit fibroblast proliferation, inflammatory cell count, edema, and angiogenesis in this animal model. We believe that future studies can elucidate on laryngotracheal wound healing as well as their molecular mechanisms.
dc.identifier.citationBiçer, Y. Ö., Köybaşı, S., Süslü, A. E., Kükner, A., Tezcan, E. ve Ulaş, N. (2014). Effect of heparin on inflammation: An animal model of tracheal stents. Laryngoscope, 124(9), E368-E372. https://dx.doi.org/10.1002/lary.24684
dc.identifier.doi10.1002/lary.24684
dc.identifier.endpageE372
dc.identifier.issn0023-852X
dc.identifier.issn1531-4995
dc.identifier.issue9
dc.identifier.scopusqualityQ1
dc.identifier.startpageE368
dc.identifier.urihttps://dx.doi.org/10.1002/lary.24684
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3375
dc.identifier.volume124
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-Blackwell
dc.relation.ispartofLaryngoscopeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectHeparin
dc.subjectTrachea
dc.subjectStenosis
dc.titleEffect of heparin on inflammation: An animal model of tracheal stents
dc.typeArticle

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