The association between calreticulin and glucagon-like peptide-1 expressions with prognostic factors in high-grade gliomas

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dc.authorid0000-0002-1847-2562
dc.contributor.authorBaran, Oğuz
dc.contributor.authorAkgün, Mehmet Yiğit
dc.contributor.authorKayhan, Ahmet
dc.contributor.authorEvran, Şevket
dc.contributor.authorÖzbek, Muhammet Arif
dc.contributor.authorAkyoldaş, Göktuğ
dc.contributor.authorSamancı, Mustafa Yavuz
dc.contributor.authorDemirel, Nail
dc.contributor.authorSönmez, Derya
dc.contributor.authorSerin, Huriye
dc.contributor.authorKoçak, Ayhan
dc.contributor.authorKemerdere, Rahşan
dc.date.accessioned2024-07-01T09:15:57Z
dc.date.available2024-07-01T09:15:57Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.description.abstractObjective: The aim of this study is to present the expressions of Calreticulin (CALR) and Glucagon-like peptide-1 (GLP-1) in high-grade gliomas and to further show the relation between the levels of these molecules and Ki-67 index, presence of Isocitrate dehydrogenase (IDH)-1 mutation, and tumor grade. Patients and Methods: A total of 43 patients who underwent surgical resection due to high-grade gliomas (HGG) (grades III and IV) were included. The control group comprised 27 people who showed no gross pathology in the brain during the autopsy procedures. Adequately sized tumor samples were removed from each patient during surgery, and cerebral tissues were removed from the control subjects during the autopsy procedures. Each sample was stored at -80°C as rapidly as possible until the enzyme assay. Results: Patients with high-grade gliomas showed significantly higher levels of CALR and significantly lower levels of GLP-1 when compared to control subjects (P = 0.001). CALR levels were significantly higher, GLP-1 levels were significantly lower in grade IV gliomas than those in grade III gliomas (P = 0.001). Gliomas with negative IDH-1 mutations had significantly higher CALR expressions and gliomas with positive IDH-1 mutations showed significantly higher GLP-1 expressions (P = 0.01). A positive correlation between Ki-67 and CALR and a negative correlation between Ki-67 and GLP-1 expressions were observed in grade IV gliomas (P = 0.001). Conclusions: Our results showed that higher CALR and lower GLP-1 expressions are found in HGGs compared to normal cerebral tissues.
dc.description.sponsorshipTurkish Neurosurgical Societyen_US
dc.identifier.citationBaran, O., Akgün, M. Y., Kayhan, A., Evran, Ş., Özbek, A., Akyoldaş, G. ... Kemerdere, R. (2024). The association between calreticulin and glucagon-like peptide-1 expressions with prognostic factors in high-grade gliomas. Journal of Cancer Research and Therapeutics, 20(1), 25-32. http://dx.doi.org/10.4103/jcrt.jcrt_1519_22
dc.identifier.doi10.4103/jcrt.jcrt_1519_22
dc.identifier.endpage32
dc.identifier.issn0973-1482
dc.identifier.issn1998-4138
dc.identifier.issue1
dc.identifier.pmid38554294
dc.identifier.scopus2-s2.0-85189369257
dc.identifier.scopusqualityQ3
dc.identifier.startpage25
dc.identifier.urihttp://dx.doi.org/10.4103/jcrt.jcrt_1519_22
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12675
dc.identifier.volume20
dc.identifier.wos001229463200027en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzbek, Arif
dc.language.isoen
dc.relation.ispartofJournal of Cancer Research and Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCalreticulin
dc.subjectGlioma
dc.subjectGlucagon-Like Peptide-1
dc.subjectSurgery
dc.subjectTumor Immunity
dc.titleThe association between calreticulin and glucagon-like peptide-1 expressions with prognostic factors in high-grade gliomas
dc.typeArticle

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