Risk factors for idiopathic granulomatous mastitis recurrence after patient-tailored treatment: Do we need an escalating treatment algorithm?

Basım, Pelin; Argun, Derya; Argun, Ferit

Risk factors for idiopathic granulomatous mastitis recurrence after patient-tailored treatment: Do we need an escalating treatment algorithm?

dc.authorid	0000-0002-9452-9276
dc.contributor.author	Basım, Pelin
dc.contributor.author	Argun, Derya
dc.contributor.author	Argun, Ferit
dc.date.accessioned	2023-01-11T11:34:49Z
dc.date.available	2023-01-11T11:34:49Z
dc.date.issued	2022
dc.department	İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.description.abstract	Objective: Idiopathic granulomatous mastitis (IGM) is a rare, relapsing, benign inflammatory breast disease. Due to the conflicting etiology and differential diagnosis, the effect of varied treatment regimens on high recurrence is controversial. Therefore, we aimed to report our clinical experience in determining risk factors for recurrence after patient-tailored treatment. Methods: This study evaluated 122 patients diagnosed with IGM according to sociodemographic characteristics, reproductive history, clinical presentation, time of diagnosis and radiological examinations, treatment management, and outcomes. The patients were classified into three groups based on curative treatment settings: medical therapy alone, surgery alone, and combined therapy. Results: The rates of patients receiving medical therapy alone, surgical therapy alone, and combined therapy were 23, 15.6, and 62.4%, respectively. Low vitamin B-12 levels, accompanying rheumatological disease, complaints-fistulae, number of complaints >= 3, presence of erythema nodosum, multicentricity, and treatment modality had a significant effect on disease recurrence (p < 0.05). The effect on IGM recurrence was 2.8 times greater for the patients with lower vitamin B-12 levels, 4.5 times greater for those with rheumatological disease, 3.3 times greater for those with fistulae, 2.4 times greater for those presenting with >= 3 complaints, 2 times greater for the presence of multicentricity, 2.3 times greater for the presence of erythema nodosum, and 4.5 times greater for the patients receiving medical therapy alone. Conclusion: Describing a low-risk patient profile can be an alternative while choosing monotherapy methods. For IGM patients at high risk of recurrence, an escalating treatment system may be effective in preventing relapses.
dc.identifier.citation	Basım, P., Argun, D. ve Argun, F. (2022). Risk factors for idiopathic granulomatous mastitis recurrence after patient-tailored treatment: Do we need an escalating treatment algorithm? Breast Care, 17(2), 172-179. https://dx.doi.org/10.1159/000517399
dc.identifier.doi	10.1159/000517399
dc.identifier.endpage	179
dc.identifier.issn	1661-3791
dc.identifier.issn	1661-3805
dc.identifier.issue	2
dc.identifier.pmid	35707181
dc.identifier.scopus	2-s2.0-85113306923
dc.identifier.scopusquality	Q1
dc.identifier.startpage	172
dc.identifier.uri	https://dx.doi.org/10.1159/000517399
dc.identifier.uri	https://hdl.handle.net/20.500.12511/10286
dc.identifier.volume	17
dc.identifier.wos	000684285800001	en_US
dc.identifier.wosquality	Q4
dc.indekslendigikaynak	Web of Science
dc.indekslendigikaynak	Scopus
dc.indekslendigikaynak	PubMed
dc.institutionauthor	Basım, Pelin
dc.language.iso	en
dc.publisher	Karger
dc.relation.ispartof	Breast Care	en_US
dc.relation.publicationcategory	Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Granulomatous Mastitis
dc.subject	Idiopathic
dc.subject	Risk Factors
dc.subject	Surgical Treatment
dc.subject	Steroids
dc.subject	Combined Treatment
dc.title	Risk factors for idiopathic granulomatous mastitis recurrence after patient-tailored treatment: Do we need an escalating treatment algorithm?
dc.type	Article