Correlation between SPARC (Osteonectin) expression with immunophenotypical and invasion characteristics of pituitary adenomas

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dc.contributor.authorOnoz, Mustafa
dc.contributor.authorBaşaran, Recep
dc.contributor.authorGüçlüer, Berrin
dc.contributor.authorIşık, Nejat
dc.contributor.authorKaner, Tuncay
dc.contributor.authorSav, Aydın
dc.contributor.authorElmacı, İlhan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:37Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:37Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.description.abstractPituitary adenomas are the third most common intracranial tumors. Invasive adenomas account for only 0.1-0.2% of pituitary tumors. SPARC is a matrix glycoprotein that plays a role in progression and invasiveness of neoplasms. In this study, we examined the potential role of SPARC in invasive pituitary adenomas. Forty pituitary adenomas have been examined with histopathological and immunohistochemical techniques. The cohort has been classified into two groups as invasive (n = 25) and non-invasive (n = 15) utilizing the Hardy classification. Formalin fixed tissues have been stained with hematoxylin eosin. Ki-67, p53, and SPARC monoclonal antibodies have been used. We did not detect any significant difference on Ki-67, SPARC, and p53 expression patterns correlating with the pathological subtype or invasiveness. Only 24% of invasive adenomas had Ki-67 levels over 1%. A total of 67.7% non-invasive adenomas had Ki-67 levels below 1%. We did not detect any relation between SPARC levels and invasiveness of pituitary adenomas. Absence of significant SPARC expression in tumor progression, sellar dilatation, erosion and destruction suggest that SPARC scores are not related with invasiveness or progressiveness of pituitary adenomas.
dc.identifier.citationOnoz, M., Başaran, R. ve Güçlüer, B. (2015). Correlation between SPARC (Osteonectin) expression with immunophenotypical and invasion characteristics of pituitary adenomas. Apmis, 123(3), 199-204. https://dx.doi.org/10.1111/apm.12342
dc.identifier.doi10.1111/apm.12342
dc.identifier.endpage204
dc.identifier.issn0903-4641
dc.identifier.issn1600-0463
dc.identifier.issue3
dc.identifier.scopusqualityQ1
dc.identifier.startpage199
dc.identifier.urihttps://hdl.handle.net/20.500.12511/874
dc.identifier.urihttps://dx.doi.org/10.1111/apm.12342
dc.identifier.volume123
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBlackwell Munksgaard
dc.relation.ispartofApmisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectSPARC
dc.subjectInvasive
dc.subjectOsteonectin
dc.subjectP53
dc.subjectPituitary Adenoma
dc.titleCorrelation between SPARC (Osteonectin) expression with immunophenotypical and invasion characteristics of pituitary adenomas
dc.typeArticle

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