Interleukin-8 in febrile neutropenic children with cancers: Its diagnostic value for bacteremia/sepsis is superior to that of interleukin-6, mannose binding lectin, procalcitonin and C-reactive protein

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dc.authorid0000-0001-8489-7449
dc.contributor.authorAkçay, Arzu
dc.contributor.authorAğaoğlu, Leyla
dc.contributor.authorEkmekçi, Hakan
dc.contributor.authorBalcı Ekmekçi, Özlem
dc.contributor.authorSarıbeyoğlu, Ebru
dc.contributor.authorAtay, Didem
dc.contributor.authorTuğcu, Deniz
dc.contributor.authorKarakaş, Zeynep
dc.contributor.authorÜnüvar, Ayşegül
dc.contributor.authorAnak, Sema
dc.contributor.authorÖztürk, Gülyüz
dc.contributor.authorDevecioğlu, Ömer
dc.date.accessioned2021-10-26T09:56:31Z
dc.date.available2021-10-26T09:56:31Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractThe aim of this study was to determine the predictive value of serum interleukin-6 (IL-6), interleukin-8 (IL-8), mannose binding lectin (MBL), procalcitonin (PCT) and C-reactive protein (CRP) levels for bacteremia/sepsis (B/S) at the beginning of a febrile episode in children with chemotherapy-induced febril neutropenia (FN). In a prospective study, 54 febrile neutropenic episodes from 30 pediatric cancer patients were analysed. Samples were obtained in two different clinical periods: afebrile neutropenic (AFN) period after chemotherapy and FN period (on the first day of fever). The highest levels of IL-6, IL-8, MBL and PCT were observed in cases of B/S group. However, only IL-8 levels were significantly higher in patients with B/S than those with clinically or microbiologically documented infection and those with fever of unknown origin (p<0.05). While sensitivity was high for IL-6 and IL-8, specificity value was found to be quite low. The marker with the highest specificity values was PCT. While positive predictive values of all markers were generally low, their negative predictive values were higher. The high levels of IL-8 are more reliable than the levels of IL-6, MBL, CRP and PCT for prediction of B/S in pediatric cancer patients with FN. With the combined use of inflammatory markers and cytokines, the low-risk group for B/S can be determined more clearly in patients with FN at the beginning of the febrile episode.
dc.description.sponsorshipIstanbul Universityen_US
dc.identifier.citationAkçay, A., Ağaoğlu, L., Ekmekçi, H., Balcı Ekmekçi, Ö., Sarıbeyoğlu, E., Atay, D. ... Devecioğlu, Ö. (2021). Interleukin-8 in febrile neutropenic children with cancers: Its diagnostic value for bacteremia/sepsis is superior to that of interleukin-6, mannose binding lectin, procalcitonin and C-reactive protein. International Journal of Hematology and Oncology, 31(4), 230-238. https://dx.doi.org/10.4999/uhod.215278
dc.identifier.doi10.4999/uhod.215278
dc.identifier.endpage238
dc.identifier.issn1306-133X
dc.identifier.issue4
dc.identifier.scopusqualityQ4
dc.identifier.startpage230
dc.identifier.urihttps://dx.doi.org/10.4999/uhod.215278
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8521
dc.identifier.volume31
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAkad Doktorlar Yayinevi
dc.relation.ispartofInternational Journal of Hematology and Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFebrile Neutropenia
dc.subjectBacteremia/Sepsis
dc.subjectInflammatory Cytokines
dc.subjectChildhood Cancer
dc.titleInterleukin-8 in febrile neutropenic children with cancers: Its diagnostic value for bacteremia/sepsis is superior to that of interleukin-6, mannose binding lectin, procalcitonin and C-reactive protein
dc.typeArticle

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