Expression of cytotoxic T lymphocyte-associated antigen 4, CD44, and E-cadherin in the microenvironment of breast carcinomas

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dc.authorid0000-0001-7036-9813
dc.contributor.authorBölme Şavlı, Tuğçe
dc.contributor.authorPaşaoğlu, Hüsniye Esra
dc.contributor.authorŞavlı, Taha Cumhan
dc.contributor.authorMuhammedoğlu, Ali
dc.contributor.authorTokoçin, Merve
dc.contributor.authorÖztürk, Çiğdem
dc.date.accessioned2023-08-10T06:44:59Z
dc.date.available2023-08-10T06:44:59Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractOBJECTIVE: The expression of cytotoxic T lymphocyte-associated antigen 4, E-cadherin, and CD44 in the area of tumor budding was investigated in breast carcinomas in our study. METHODS: Tumor budding was counted at the invasive margins in 179 breast carcinomas. To understand the microenvironment of tumor budding, we examined the expression status of the immune checkpoint molecules such as cytotoxic T lymphocyte-associated antigen 4, E-cadherin, and CD44. RESULTS: Tumors were separated into low (?5) and high tumor budding groups (>5) based on the median budding number. Lymphovascular, perineural invasion, and the number of metastatic lymph nodes were significantly higher in high-grade budding tumors (p=0.001, p<0.001, and p=0.019, respectively). Tumor-infiltrating lymphocytes were significantly higher in tumors without tumor buddings (p[removed]
dc.identifier.citationBölme Şavlı, T., Paşaoğlu, H. E., Şavlı, T. C., Muhammedoğlu, A., Tokoçin, M. ve Öztürk, Ç. (2023). Expression of cytotoxic T lymphocyte-associated antigen 4, CD44, and E-cadherin in the microenvironment of breast carcinomas. Revista da Associacao Medica Brasileira (1992), 69(7), e20230371-e20230371. https://dx.doi.org/10.1590/1806-9282.20230371
dc.identifier.doi10.1590/1806-9282.20230371
dc.identifier.endpagee20230371
dc.identifier.issn0104-4230
dc.identifier.issn1806-9282
dc.identifier.issue7
dc.identifier.pmid37466609
dc.identifier.scopus2-s2.0-85165519428
dc.identifier.scopusqualityQ3
dc.identifier.startpagee20230371
dc.identifier.urihttps://dx.doi.org/10.1590/1806-9282.20230371
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11295
dc.identifier.volume69
dc.identifier.wos001033719400005en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞavlı, Taha Cumhan
dc.language.isoen
dc.publisherNLM (Medline)
dc.relation.ispartofRevista da Associacao Medica Brasileira (1992)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBreast Neoplasms
dc.subjectCD44 Protein
dc.subjectMouse
dc.subjectCTLA-4 Antigen
dc.subjectE-Cadherin
dc.subjectTumor Microenvironment
dc.titleExpression of cytotoxic T lymphocyte-associated antigen 4, CD44, and E-cadherin in the microenvironment of breast carcinomas
dc.typeArticle

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