LDH-A inhibitor as a remedy to potentiate the anticancer effect of docetaxel in prostate cancer

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dc.authorid0000-0002-8662-5284
dc.authorid0000-0002-8302-1127
dc.authorid0000-0002-5919-1986
dc.authorid0000-0002-0675-1839
dc.contributor.authorÇakıcı, Çağrı
dc.contributor.authorDaylan, Benay
dc.contributor.authorÜnlüer, Rüveyde Safiye
dc.contributor.authorEmekli Alturfan, Ebru
dc.contributor.authorAyla, Şule
dc.contributor.authorEren Gözel, Hilal
dc.contributor.authorYiğit, Pakize
dc.contributor.authorYavuz Dokgöz, Elif
dc.contributor.authorYiğitbaşı, Türkan
dc.date.accessioned2024-03-08T07:57:40Z
dc.date.available2024-03-08T07:57:40Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik ve Tıp Bilişimi Ana Bilim Dalı
dc.description.abstractIncreased LDH-A activity promotes tumor growth, migration, invasion, and metastasis. This study aimed to investigate the effects of the combination of LDH-A inhibitor and Docetaxel on apoptosis and epithelial-mesenchymal transition (EMT) in the murine prostate cancer (PCa) model. The prostate cancer murine model was developed subcutaneously in 50 male B57CL/6 mice using the Tramp-C2 prostate cancer cell line. From the tumor tissue samples, apoptosis analysis was performed using TUNEL staining, and EMT was investigated using western blot and qPCR. Hematoxylin-eosin staining (HE) and Periodic acid-Schiff staining were used to histopathologically examine liver and kidney tissues. Lactate levels revealed that the Warburg effect was reversed with the LDH-A inhibitor. Both serum and tumor tissue apoptosis increased, and tumor sizes reduced in PCa+LDH-A inhibitor + Docetaxel treatment groups (p<0.05). The combination of LDH-A inhibitor and Docetaxel inhibited EMT mechanism by causing a decrease in Snail, Slug, Twist, and HIF-1? expressions as well as a decrease in N-cadherin and an increase in E-cadherin levels. Reprogramming glucose metabolism with an LDH-A inhibitor can increase the effectiveness of Docetaxel on apoptosis and metastasis mechanisms in PCa.
dc.description.sponsorshipIstanbul Medipol University Scientific Research Projects Uniten_US
dc.identifier.citationÇakıcı, Ç., Daylan, B., Ünlüer, R. S., Emekli Alturfan, E., Ayla, Ş., Eren Gözel, H. ... Yiğitbaşı, T. (2024). LDH-A inhibitor as a remedy to potentiate the anticancer effect of docetaxel in prostate cancer. Journal of Cancer, 15(3), 590-602. https://dx.doi.org/10.7150/jca.86283
dc.identifier.doi10.7150/jca.86283
dc.identifier.endpage602
dc.identifier.issn1837-9664
dc.identifier.issue3
dc.identifier.pmid38213726
dc.identifier.scopus2-s2.0-85185716416
dc.identifier.scopusqualityQ2
dc.identifier.startpage590
dc.identifier.urihttps://dx.doi.org/10.7150/jca.86283
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12348
dc.identifier.volume15
dc.identifier.wos001167297900004en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇakıcı, Çağrı
dc.institutionauthorDaylan, Benay
dc.institutionauthorÜnlüer, Rüveyde Safiye
dc.institutionauthorYiğit, Pakize
dc.institutionauthorYiğitbaşı, Türkan
dc.language.isoen
dc.publisherIvyspring International Publisher
dc.relation.ispartofJournal of Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/119S850
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectApoptosis
dc.subjectEMT
dc.subjectLDH-A Inhibitor
dc.subjectProstate Cancer
dc.subjectWarburg Effect
dc.titleLDH-A inhibitor as a remedy to potentiate the anticancer effect of docetaxel in prostate cancer
dc.typeArticle

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