Platelet-rich plasma for laryngotracheal reconstruction: An experimental study

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dc.contributor.authorŞahin Önder, Serap
dc.contributor.authorŞahin Yılmaz, Aslı
dc.contributor.authorErkmen, Burak
dc.contributor.authorTopal, Cumhur Selçuk
dc.contributor.authorGergin, Özgül
dc.contributor.authorCanpolat, Mustafa Salih
dc.date.accessioned2020-10-26T11:01:31Z
dc.date.available2020-10-26T11:01:31Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kulak Burun Boğaz Hastalıkları Ana Bilim Dalı
dc.description.abstractObjectives/hypothesis This study was designed to evaluate the graft healing effect of topical application of platelet-rich plasma (PRP) for laryngotracheal reconstruction (LTR) in a rabbit model. Study design It is a prospective randomized control animal study. Materials and methods Sixteen healthy New Zealand White rabbits were assigned to two groups of eight animals each. The control group underwent LTR with anterior auricular cartilage graft. The PRP group underwent the same surgical procedure plus PRP application over the anastomosis and surgical field. Two animals in the PRP group and two animals in control group died due to severe respiratory distress on postoperative days 10, 12, 15, and 18. Six rabbits (n = 3 for control group and n = 3 for PRP group) were sacrificed at 4 weeks, and six rabbits (n = 3 for control group and n = 3 for PRP group) were sacrificed at 8 weeks. Laryngotracheal regions were evaluated histopathologically. Results Macroscopically, the average anteroposterior and lateral diameter of the reconstructed region and the degree of lumen patency on postoperative 4th week and 8th week were not statistically different among two groups. There was no significant difference between the groups in terms of any of the microscopic findings when the analysis was made separately. However, analysis of the total number of rabbits has shown that new cartilage formation and angiogenesis were more pronounced in PRP group than control group. Conclusions Application of PRP contributed to better healing in airway surgery by promoting a release of growth factors that stimulate new cartilage formation and angiogenesis.
dc.description.sponsorshipScience Research Program of Health Sciences Universityen_US
dc.identifier.citationŞahin Önder, S., Şahin Yılmaz, A., Erkmen, B., Topal, C. S., Gergin, Ö. ve Canpolat, M. S. (2020). Platelet-rich plasma for laryngotracheal reconstruction: An experimental study. European Archives of Oto-Rhino-Laryngology, 277(11), 3103-3109. https://dx.doi.org/10.1007/s00405-020-06091-8
dc.identifier.doi10.1007/s00405-020-06091-8
dc.identifier.endpage3109
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.issue11
dc.identifier.scopusqualityQ1
dc.identifier.startpage3103
dc.identifier.urihttps://dx.doi.org/10.1007/s00405-020-06091-8
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5973
dc.identifier.volume277
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofEuropean Archives of Oto-Rhino-Laryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectPlatelet-Rich Plasma
dc.subjectLaryngotracheal Reconstruction
dc.subjectWound Healing
dc.titlePlatelet-rich plasma for laryngotracheal reconstruction: An experimental study
dc.typeArticle

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