Genetic polymorphisms of Cyp19 and myostatin genes in Turkish indigenous sheep breeds

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dc.authorid0000-0002-6183-5015
dc.contributor.authorAkış, Iraz
dc.contributor.authorEsen Gürsel, Feraye
dc.contributor.authorHacıhasanoğlu Çakmak, Neziha
dc.contributor.authorAtmaca, Gizem
dc.contributor.authorYardibi, Hasret
dc.contributor.authorAteş, Atilla
dc.contributor.authorDurak, Mehmet Hanifi
dc.contributor.authorÖztabak, Kemal
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:31Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:31Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Laboratuvar Teknikleri Ana Bilim Dalı
dc.descriptionWOS: 000418954600008
dc.description.abstractGrowth and meat production traits are very important in sheep breeding. Cyp19 gene has a major role in reproductive activity and growth due to its function in estrogen synthesis. Another gene affecting growth traits is Myostatin (MSTN) gene, which mainly regulates skeletal muscle growth. In this study allele frequencies of genetic polymorphism in Cyp19 and Myostatin genes were identified by PCR-RFLP method in five indigenous Turkish sheep breeds, Chiose, Imroz, Kivircik, Zom and Morkaraman. Digestion of Cyp19 gene with HaeIII only revealed uncut AA genotype and digestion of MSTN with DraI also revealed only uncut AA genotype. Both loci analyzed in this study were found to be monomorphic in five Turkish indigenous sheep breeds. These highly conserved parts of the two genes can be useful for molecular evolutionary studies in sheep. Further studies regarding association analysis of Cyp19 and MSTN in sheep should be conducted.
dc.description.sponsorshipIstanbul University, Faculty of Veterinary Medicine [VET-TB-16-1, VET-TB-16-2, BEK-2016-22550, BEK-2017-24900]en_US
dc.description.sponsorshipThis study was supported by Istanbul University, Faculty of Veterinary Medicine with project numbers VET-TB-16-1, VET-TB-16-2, BEK-2016-22550 and BEK-2017-24900en_US
dc.identifier.citationAkış, I., Esen Gürsel, F., Hacıhasanoğlu Çakmak, N., Atmaca, G., Yardibi, H., Ateş, A. ... Öztabak, K. (2017). Genetic polymorphisms of Cyp19 and myostatin genes in Turkish indigenous sheep breeds. Journal of Hellenic Veterinary Medical Society, 68(3), 313-318.
dc.identifier.endpage318
dc.identifier.issn1792-2720
dc.identifier.issue3
dc.identifier.scopusqualityQ4
dc.identifier.startpage313
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3323
dc.identifier.volume68
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherHellenic Veterinary Medical Society
dc.relation.ispartofJournal of Hellenic Veterinary Medical Societyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectCyp19
dc.subjectMyostatin
dc.subjectSheep
dc.subjectSNP
dc.subjectPCR-RFLP
dc.titleGenetic polymorphisms of Cyp19 and myostatin genes in Turkish indigenous sheep breeds
dc.typeArticle

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