Effect of terlipressin infusion therapy on recipient's hepatic and renal functions in living donor liver transplantations: Experience from a tertiary hospital

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dc.authorid0000-0002-5273-1871
dc.contributor.authorKaraaslan, Pelin
dc.contributor.authorSevmiş, Şinasi
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:43Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:43Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.descriptionWOS: 000458370600019
dc.descriptionPubMed ID: 30729953
dc.description.abstractBackground: Patients with end-stage liver disease are prone to hemodynamic disturbances which may be aggravated with liver transplantation. Blood pooling in splanchnic area and portal hypertension cause reduction in central blood volume. Terlipressin reduces mesenteric and hepatic blood flow, causing vasoconstriction in the smooth muscles of the arteries in the splanchnic region. Objective: We investigated the efficacy of perioperative terlipressin infusion in patients who received living donor liver transplantation (LDLT) on hepatic and renal functions. Design: Retrospective. Setting: University hospital. Method: The study included 86 adult patients who received LDLT, due to end-stage hepatic disease, between April 2014 and July 2016 in our institute. Data were collected by searching the medical archives of patients. A standard anesthesia protocol was administered to all patients. In a selected group of patients, terlipressin infusion was initiated at 3 mg/kg/h, immediately after anesthesia was induced. The dose was halved following arterial anastomosis and was continued at this dose for the subsequent 3 days. Patients who received terlipressin infusion were compared with patients who did not receive it. Main Outcome Measures: There is no evidence in this trial to show evidence of effectiveness as a result of terlipressin infusion. Results: Patients in the terlipressin group were statistically significantly older. Central venous pressure, cardiac index, global end diastolic volume, and extravascular lung volume did not show significant differences between the groups. Urine output was similar in both groups; however, regarding the use of packed red blood cells and fresh frozen plasma, terlipressin group patients needed more packs. Perioperative liver function tests were similar between the groups except for aspartate aminotransferase and alanine aminotransferase values on the first and third postoperative days. Conclusion: Terlipressin infusion was not found to be significantly effective among the liver and kidney function tests. Limitations: This may be a result of randomization defect of our retrospective study design. Many prospective randomized studies should be planned to reach more accurate results.
dc.identifier.citationKaraaslan, P. ve Sevmiş, Ş. (2019). Effect of terlipressin infusion therapy on recipient's hepatic and renal functions in living donor liver transplantations: Experience from a tertiary hospital. Nigerian Journal of Clinical Practice, 22(2), 265-269. https://dx.doi.org/10.4103/njcp.njcp_268_17
dc.identifier.doi10.4103/njcp.njcp_268_17
dc.identifier.endpage269
dc.identifier.issn1119-3077
dc.identifier.issue2
dc.identifier.scopusqualityQ3
dc.identifier.startpage265
dc.identifier.urihttps://dx.doi.org/10.4103/njcp.njcp_268_17
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1735
dc.identifier.volume22
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofNigerian Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectHepatic Function Tests
dc.subjectLiving Related Donor Liver Transplantation
dc.subjectTerlipressin
dc.titleEffect of terlipressin infusion therapy on recipient's hepatic and renal functions in living donor liver transplantations: Experience from a tertiary hospital
dc.typeArticle

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