Prostaglandin E2 levels of aqueous and vitreous humor in ketorolac 0.4% and nepafenac 0.1% administered healthy rabbits

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dc.authorid0000-0003-2445-6339
dc.contributor.authorAcar, Uğur
dc.contributor.authorErgintürk Acar, Damla
dc.contributor.authorTanrıverdi, Cafer
dc.contributor.authorAcar, Mutlu
dc.contributor.authorÖzdemir, Özdemir
dc.contributor.authorErikci, Açelya
dc.contributor.authorÖrnek, Firdevs
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:12Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:12Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000405391300005
dc.descriptionPubMed ID: 26765265
dc.description.abstractPurpose: To compare the lowering effects of ketorolac 0.4% and nepafenac 0.1% on aqueous and vitreous humor prostaglandin E-2 (PGE(2)) levels in rabbits.Methods: Ketorolac and nepafenac ophthalmic solutions were administered to the right eyes of 24 healthy rabbits after randomized division into two groups. The left eyes of these rabbits were considered as controls for the two groups. On the 4th day of the experiment, the samples were taken from the aqueous and vitreous humors of the rabbits bilaterally, and PGE(2) levels were measured by an enzyme immune assay kit.Results: Ketorolac and nepafenac achieved a statistically significant decrease (p<0.001, for each) in PGE(2) levels in the aqueous (11.75 6.15 and 14.75 +/- 7.60 pg/mL, respectively) and the vitreous humor (6.58 +/- 4.62 and 9.83 +/- 4.55 pg/mL, respectively).Conclusions: Both ketorolac and nepafenac inhibited PGE(2) levels in both the aqueous and vitreous humors of rabbits. Although PGE(2)-lowering effects were similar in the aqueous humor, nepafenac seemed to be more potent than ketorolac in the vitreous humor.
dc.identifier.citationAcar, U., Ergintürk Acar, D., Tanrıverdi, C., Acar, M., Özdemir, Ö., Erikçi, A. ... Örnek, F. (2017). Prostaglandin E2 levels of aqueous and vitreous humor in ketorolac 0.4% and nepafenac 0.1% administered healthy rabbits. Ocular Immunology and Inflammation, 25(3), 323-327. https://dx.doi.org/10.3109/09273948.2015.1116587
dc.identifier.doi10.3109/09273948.2015.1116587
dc.identifier.endpage327
dc.identifier.issn0927-3948
dc.identifier.issn1744-5078
dc.identifier.issue3
dc.identifier.scopusqualityQ2
dc.identifier.startpage323
dc.identifier.urihttps://dx.doi.org/10.3109/09273948.2015.1116587
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3582
dc.identifier.volume25
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc.
dc.relation.ispartofOcular Immunology and Inflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAmfenac
dc.subjectAqueous Humor
dc.subjectKetorolac
dc.subjectNepafenac
dc.subjectPGE(2)
dc.subjectVitreous Humor
dc.titleProstaglandin E2 levels of aqueous and vitreous humor in ketorolac 0.4% and nepafenac 0.1% administered healthy rabbits
dc.typeArticle

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