An animal model of effects of nicotine exposure on endometrial receptivity and embryo implantation in pregnancy

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dc.authorid0000-0003-0128-6947
dc.contributor.authorAkpak, Yaşam Kemal
dc.contributor.authorÇekmez, Yasemin
dc.contributor.authorErdoğan Çakır, Aslı
dc.contributor.authorKaraca, Nilay
dc.contributor.authorBatmaz, Gonca
dc.contributor.authorGülşen, Serdar
dc.contributor.authorHaberal, Esra Tuştaş
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:58:32Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:58:32Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.descriptionWOS: 000413763400009
dc.descriptionPubMed ID: 27884089
dc.description.abstractObjective: This study aims at evaluating the endometrial receptivity in uterus of pregnant rats exposed to nicotine via examination of integrin expression by immunohistochemical effect. Methods: In this study, 16 healthy pregnant rats were divided into two groups of control and study groups each comprising eight rats. The rats randomised to study group were given a certain amount of nicotine before and during the pregnancy. Integrin expression was detected in uterus of all rats by immunohistochemical staining. The effect of nicotine exposure on embryo implantation and the endometrial receptivity were immunohistochemically and pathologically evaluated. Results: Comparison of both groups revealed no difference in living, viable foetuses. Intensity and universality of immunohistochemical staining of Integrin 3 for endometrial epithelium and endometrial stroma were detected to be identical between the groups. Conclusion: No immunochemical effect was observed on integrin expression, which is a very important part of receptivity in an animal model created with pregnant rats that were transdermally exposed to nicotine. Our study demonstrated that the harmful effect of nicotine use before and pregnancy on implantation is limited at the level of integrin expression, in a dose-dependent manner and also by considering the method of administration.
dc.identifier.citationAkpak, Y. K., Çekmez, Y., Erdoğan Çakır, A., Karaca, N., Batmaz, G., Gülşen, S. ... Haberal, E. T. (2017). An animal model of effects of nicotine exposure on endometrial receptivity and embryo implantation in pregnancy. Journal of Maternal-Fetal & Neonatal Medicine, 30(23), 2818-2823. https://dx.doi.org/10.1080/14767058.2016.1265499
dc.identifier.doi10.1080/14767058.2016.1265499
dc.identifier.endpage2823
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue23
dc.identifier.scopusqualityQ2
dc.identifier.startpage2818
dc.identifier.urihttps://dx.doi.org/10.1080/14767058.2016.1265499
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3187
dc.identifier.volume30
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Maternal-Fetal & Neonatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectEndometrial Receptivity
dc.subjectImplantation
dc.subjectIntegrin
dc.subjectSmoking
dc.subjectTobacco
dc.titleAn animal model of effects of nicotine exposure on endometrial receptivity and embryo implantation in pregnancy
dc.typeArticle

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