Schiff base-poloxamer p85 combination prevents prostate cancer progression in c57/bl6 mice

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dc.authorid0000-0002-6242-3709
dc.authorid0000-0001-6494-8923
dc.contributor.authorDo?an, Ayşegül
dc.contributor.authorDemirci, Selami
dc.contributor.authorBaşak Türkmen, Neşe
dc.contributor.authorÇağlayan, Ahmet Burak
dc.contributor.authorAydın, Safa
dc.contributor.authorTelci, Dilek
dc.contributor.authorKılıç, Ertuğrul
dc.contributor.authorŞahin, Kazım
dc.contributor.authorOrhan, Cemal
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorDoğan Ekici, Asiye Işın
dc.contributor.authorŞahin, Fikrettin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:41Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:41Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.descriptionWOS: 000384547100011
dc.descriptionPubMed ID: 27338565
dc.description.abstractBACKGROUNDProstate cancer which is the second most common cause of death among men has a high incidence in recent years. Current therapeutic regimens should be improved to overcome drug resistance. At the metastatic stage, tumors become refractory to established chemotherapeutic treatments and cause serious problems at the clinics. Development of new drug molecules that are able to transport through the membrane easily and kill tumor cells rapidly is of great interest. METHODIn the current study, a novel Heterodinuclear copper(II)Mn(II) Schiff base complex combined with P85 was used for prostate cancer treatment in vivo. Tramp-C1 cells injected animals were subjected to chemotherapeutic formulation treatment and results were analyzed by toxicology analysis, tumor volume measurements, and histopathological analysis. 0.5mg/kg Schiff base was selected and combined with 0.05% P85 according to the toxicology analysis showing the enzyme levels, blood parameters, and multiple organ toxicity. RESULTSResults demonstrated that Heterodinuclear copper(II)Mn(II) complex-P85 combination decreased tumor formation and tumor volume steadily over the course of experiments. CONCLUSIONSOverall, Heterodinuclear copper(II)Mn(II) complex-P85 exerted remarkable anti-cancer activity in vivo in C57/B16 mice. Prostate 76:1454-1463, 2016.
dc.identifier.citationDo?an, A., Demirci, S., Başak Türkmen, N., Çağlayan, A. B., Aydın, S., Telci, D. ... Şahin, F. (2016). Schiff base-poloxamer p85 combination prevents prostate cancer progression in c57/bl6 mice. Prostate, 76(15), 1454-1463. https://dx.doi.org/10.1002/pros.23229
dc.identifier.doi10.1002/pros.23229
dc.identifier.endpage1463
dc.identifier.issn0270-4137
dc.identifier.issn1097-0045
dc.identifier.issue15
dc.identifier.scopusqualityQ1
dc.identifier.startpage1454
dc.identifier.urihttps://dx.doi.org/10.1002/pros.23229
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3708
dc.identifier.volume76
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofProstateen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSchiff Base
dc.subjectPluronic
dc.subjectP85
dc.subjectProstate Cancer
dc.subjectTramp-C1
dc.titleSchiff base-poloxamer p85 combination prevents prostate cancer progression in c57/bl6 mice
dc.typeArticle

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