Can CAPRIN-1 be responsible for the recurrence potential of odontogenic keratocysts?

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dc.authorid0000-0001-9860-5494
dc.contributor.authorYıldırımyan, Nelli
dc.contributor.authorAltay, Mehmet Ali
dc.contributor.authorÖzbudak, İrem Hicran
dc.date.accessioned2024-07-29T11:58:40Z
dc.date.available2024-07-29T11:58:40Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Ağız, Diş ve Çene Cerrahisi Ana Bilim Dalı
dc.description.abstractObjectives: The purpose of this retrospective study is to compare dentigerous cysts and odontogenic keratocysts for cytoplasmic activation/proliferation - associated protein-1 antibodies via immunohistochemical staining to obtain a new perspective about the specific behavioural characteristics of odontogenic keratocysts at the molecular level. Material and Methods: Forty dentigerous cysts (DC) and forty odontogenic keratocysts (OKC) tissue samples were examined using immunohistochemical staining to detect cytoplasmic activation/proliferation - associated protein-1 (CAPRIN-1) antibodies. Nuclear and/or cytoplasmic staining was evaluated as "positive". Cell staining rate (%) and cell staining intensity were determined, and a staining intensity distribution (SID) score was calculated for each sample. Cases were considered "negative" if they showed no staining for CAPRIN-1 antibodies, thus were given a SID score of zero. According to the SID scores, the expression levels were rated as negative, mild, moderate, or high. Results: Of 80 samples, 16 that could adversely affect immunohistochemical evaluation were excluded. Ten negative, 21 positive and three negative, 30 positive CAPRIN-1 expressions were observed in DC and OKC groups, respectively. The difference between the negative and positive cases within groups was significant only in the OKC group (P = 0.000). The SID score range and mean were 0 to 160 and 31.1 (SD 35.7) for DC and 0 to 160 and 57.3 (SD 42.3) for OKC groups. CAPRIN-1 expression was significantly higher in the OKC group (P = 0.043). Conclusions: The molecular basis for increased mitotic activity, high recurrence rates or presence of satellite cysts in odontogenic keratocysts may be attributed to the expression of cytoplasmic activation/proliferation - associated protein-1.
dc.description.sponsorshipAkdeniz Universityen_US
dc.identifier.citationYıldırımyan, N., Altay, M. A. ve Özbudak, İ. H. (2024). Can CAPRIN-1 be responsible for the recurrence potential of odontogenic keratocysts?. Jomr-Journal of Oral & Maxillofacial Research, 15(2). http://dx.doi.org/10.5037/jomr.2024.15204
dc.identifier.doi10.5037/jomr.2024.15204
dc.identifier.issn2029-283X
dc.identifier.issue2
dc.identifier.pmid39139357
dc.identifier.urihttp://dx.doi.org/10.5037/jomr.2024.15204
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12744
dc.identifier.volume15
dc.identifier.wos001266321100001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorYıldırımyan, Nelli
dc.language.isoen
dc.relation.ecinfo:eu-repo/grantAgreement/EC/FP7/TDH-2019-4239
dc.relation.ispartofJomr-Journal of Oral & Maxillofacial Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCell Proliferation
dc.subjectDentigerous Cyst
dc.subjectJaw Cysts
dc.subjectOdontogenic Cysts
dc.subjectRecurrence
dc.titleCan CAPRIN-1 be responsible for the recurrence potential of odontogenic keratocysts?
dc.typeArticle

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