Pleiotropic effects of pitavastatin: A pilot study using the saphenous vein endothelial cell model of endothelial injury and prevention of atherosclerosis

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dc.authorid0000-0001-6643-9364
dc.contributor.authorAlaylıoğlu, Merve
dc.contributor.authorYenmiş, Güven
dc.contributor.authorDoğan, A. S.
dc.contributor.authorDursun, E.
dc.contributor.authorGezen Ak, Duygu
dc.contributor.authorUğurlucan, Murat
dc.contributor.authorÖnal, Burak
dc.date.accessioned2022-08-22T07:48:31Z
dc.date.available2022-08-22T07:48:31Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalı
dc.description.abstractOBJECTIVE: Cardiovascular diseases are responsible for the majority of deaths on a global scale. Atherosclerosis is the main risk factor for cardiovascular disorders and represents a complex phenomenon associated with endothelial dysfunction and inflammation. Statins, especially atorvastatin (ATV) and pitavastatin (PTV), are common agents used to control ongoing atherosclerotic events in the body to minimize cardiovascular disease-based deaths. MATERIALS AND METHODS: The present study aimed at comparing the efficacy of ATV and PTV in a cell line model of inflammation. Human saphenous vein cells were treated with TNF-alpha to mimic atherosclerotic conditions, and the cells were divided into 7 groups, including control, DMSO, TNF-alpha (10 ng/mL-6 hours), ATV (50 ?M/24 hours), PTV (2 ?M/24 hours), ATV (50 ?M/24 hours)+TNF-alpha (10 ng/ mL-6 hours) and PTV (2 ?M/24 hours)+TNF-alpha (10 ng/mL-6 hours). The expression levels of 20 proinflammatory cytokines and chemokines were investigated in these groups using a human atherosclerosis antibody array. RESULTS: Possible pathway interactions were determined by STRING and PANTHER analyses. Comparison with the effect of ATV indicated that PTV reduced the levels of 4 proinflammatory cytokines: CCL11, CSF2, CCL20, and TGFB1 (p<0.05). CONCLUSIONS: Pleiotropic effects of pitavastatin against cardiovascular diseases appeared to be better; however, additional studies are required to compare statins and to identify new drugs that maintain broader protection from the risks of cardiovascular diseases.
dc.identifier.citationAlaylıoğlu, M., Yenmiş, G., Doğan, A. S., Dursun, E., Gezen Ak, D., Uğurlucan, M. ... Önal, B. (2022). Pleiotropic effects of pitavastatin: A pilot study using the saphenous vein endothelial cell model of endothelial injury and prevention of atherosclerosis. European Review for Medical and Pharmacological Sciences, 26(14), 5210-5217. http://doi.org/10.26355/eurrev_202207_29310
dc.identifier.doi10.26355/eurrev_202207_29310
dc.identifier.endpage5217
dc.identifier.issn1128-3602
dc.identifier.issn2284-0729
dc.identifier.issue14
dc.identifier.pmid35916819
dc.identifier.scopus2-s2.0-85135557962
dc.identifier.scopusqualityQ2
dc.identifier.startpage5210
dc.identifier.urihttp://doi.org/10.26355/eurrev_202207_29310
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9664
dc.identifier.volume26
dc.identifier.wos000842441500001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorUğurlucan, Murat
dc.language.isoen
dc.publisherVerduci Editore s.r.l
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectCardiovascular Diseases
dc.subjectAtherosclerosis
dc.subjectAtorvastatin
dc.subjectPitavastatin
dc.subjectInflammation
dc.titlePleiotropic effects of pitavastatin: A pilot study using the saphenous vein endothelial cell model of endothelial injury and prevention of atherosclerosis
dc.typeArticle

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