Comparison of dexmedetomidine and midazolam in conscious sedation during dental implant surgery: A randomized clinical trial

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dc.authorid0000-0002-6705-3110
dc.contributor.authorGüldi?ken, İpek Necla
dc.contributor.authorGürler, Gökhan
dc.contributor.authorDelilbaşı, Çağrı
dc.date.accessioned2022-01-06T07:46:10Z
dc.date.available2022-01-06T07:46:10Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Ağız, Diş ve Çene Cerrahisi Ana Bilim Dalı
dc.description.abstractPurpose: Conscious sedation in oral surgical procedures provides comfort both for patients and practitioners. Midazolam is a sedative agent commonly used in this manner. Dexmedetomidine is also a decent sedative agent, with its analgesic and mild respiratory effects, which is usually preferred in intensive care units. Dexmedetomidine has been recently used in dental surgeries. This study aimed to investigate the analgesic and respiratory properties of midazolam and dexmedetomidine in conscious sedation during dental implant procedures and to compare these two drugs in terms of ease of use and comfort of dental implant operation. Materials and Methods: This study was a prospective double-blind randomized controlled study. The patients who needed dental implant placement were divided into two randomized groups for either midazolam or dexmedetomidine. The amount of sedative agent used, duration of the procedure, onset of sedation, use of additional same sedative agent, and occurrence of desaturation were recorded. Hemodynamic and respiratory variables (mean blood pressure, heart rate, oxygen saturation, and respiratory rate) were recorded every 10 minutes, starting immediately before the loading dose until the end of the procedure. Patients completed a Likert scale for their satisfaction, and patient pain was scored using the numeric rating scale postoperatively. The amount of painkiller usage was recorded and reported. All surgical procedures were performed by the same surgeon, and all recordings were taken by an anesthesiology technician; both were blinded for the randomization. Descriptive and bivariate statistics were computed, and the P value was set at < .05. Results: This study included patients who were scheduled for two to five dental implant insertions to either arch under conscious sedation. A total of 163 dental implants were inserted into 43 patients. Patients receiving dexmedetomidine had lower pain, higher satisfaction with the procedure, and less desaturation (P = .002). The onset of sedation was more rapid with midazolam (P = .001). The number of implants according to drugs did not differ statistically. On the other hand, the mean operation time was 52.09 +/- 20.12 minutes in the dexmedetomidine group and 87.14 +/- 26.15 minutes in the midazolam group (P = .001). No significant difference was found for retrograde amnesia and preference of sedative between midazolam and dexmedetomidine. Conclusion: Dexmedetomidine is a good alternative to midazolam for conscious sedation during dental implant procedures, with its better analgesic property and minimal respiratory side effects.
dc.identifier.citationGüldi?ken, İ. N., Gürler, G. ve Delilbaşı, Ç. (2021). Comparison of dexmedetomidine and midazolam in conscious sedation during dental implant surgery: A randomized clinical trial. International Journal of Oral & Maxillofacial Implants, 36(6), E158-E164. https://dx.doi.org/10.11607/jomi.8929
dc.identifier.doi10.11607/jomi.8929
dc.identifier.endpageE164
dc.identifier.issn0882-2786
dc.identifier.issn1942-4434
dc.identifier.issue6
dc.identifier.scopusqualityQ1
dc.identifier.startpageE158
dc.identifier.urihttps://dx.doi.org/10.11607/jomi.8929
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8768
dc.identifier.volume36
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherQuintessence
dc.relation.ispartofInternational Journal of Oral & Maxillofacial Implantsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnalgesia
dc.subjectConscious Sedation
dc.subjectDental Implant
dc.subjectDexmedetomidine
dc.subjectMidazolam
dc.titleComparison of dexmedetomidine and midazolam in conscious sedation during dental implant surgery: A randomized clinical trial
dc.typeArticle

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