Variables determining mortality in patients with Acinetobacter baumannii meningitis/ventriculitis treated with intrathecal colistin

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dc.authorid0000-0001-9658-7560
dc.authorid0000-0001-8022-7325
dc.authorid0000-0001-8945-2385
dc.contributor.authorCeylan, Bahadır
dc.contributor.authorArslan, Ferhat
dc.contributor.authorSipahi, Oğuz Reşat
dc.contributor.authorSünbül, Mustafa
dc.contributor.authorÖrmen, Bahar
dc.contributor.authorHakyemez, İsmail N.
dc.contributor.authorTurunç, Tuba
dc.contributor.authorYıldız, Yeşim
dc.contributor.authorKarsen, Hasan
dc.contributor.authorKaragöz, Gül
dc.contributor.authorTekin, Recep
dc.contributor.authorHizarcı, Burcu
dc.contributor.authorTurhan, Vedat
dc.contributor.authorŞenol, Şebnem
dc.contributor.authorÖztoprak, Nefise
dc.contributor.authorYılmaz, Mesut
dc.contributor.authorÖzdemir, Kevser
dc.contributor.authorMermer, Sinan
dc.contributor.authorKökoüğlu, Ömer F.
dc.contributor.authorMert, Ali
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:51:21Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:51:21Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı
dc.descriptionWOS: 000394632300009
dc.descriptionPubMed ID: 28013184
dc.description.abstractAim: To examine the variables associated with mortality in patients with Acinetobacter baumannii-related central nervous system infections treated with intrathecal colistin. Materials and methods: This multi-centre retrospective case control study included patients from 11 centres in Turkey, as well as cases found during a literature review. Only patients with CNS infections caused by multidrug-resistant or extensively drug-resistant Acinetobacter baumannii treated with intrathecal colistin were included in this study. The variables associated with mortality were determined by dividing the patients into groups who died or survived during hospitalisation, and who died or survived from Acinetobacter meningitis. Results: Among the 77 cases enrolled in the study, 35 were found through a literature review and 42 were cases from our centres. Forty-four cases (57.1%) were male and the median age was 48 years (range: 20-78 years). Thirty-seven patients (48%) died during hospitalisation. The variables associated with increased all-cause mortality during hospitalisation included old age (odds ratio, 1.035; 95% confidence interval (Cl), 1.004-1.067; p = 0.026) and failure to provide cerebrospinal fluid sterilisation (odds ratio, 0.264; 95% confidence interval, 0.097-0.724; p = 0.01). There is a trend (P=0.062) towards higher mortality with using of meropenem during meningitis treatment. Fifteen cases (19%) died from meningitis. There were no significant predictors of meningitis-related mortality. Conclusions: The mortality rate for central nervous system infections caused by multidrug-resistant or extensively drug-resistant Acinetobacter baumannii is high. Old age and failure to provide CSF sterilisation are associated with increased mortality during hospitalisation.
dc.identifier.citationCeylan, B., Arslan, F., Sipahi, O. R., Sünbül, M., Örmen, B., Hakyemez, İ. N. ... Mert, A. (2017). Variables determining mortality in patients with Acinetobacter baumannii meningitis/ventriculitis treated with intrathecal colistin. Clinical Neurology and Neurosurgery, 153, 43-49. https://dx.doi.org/10.1016/j.clineuro.2016.12.006
dc.identifier.doi10.1016/j.clineuro.2016.12.006
dc.identifier.endpage49
dc.identifier.issn0303-8467
dc.identifier.issn1872-6968
dc.identifier.scopusqualityQ2
dc.identifier.startpage43
dc.identifier.urihttps://dx.doi.org/10.1016/j.clineuro.2016.12.006
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2201
dc.identifier.volume153
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bv.
dc.relation.ispartofClinical Neurology and Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcinetobacter Baumannii
dc.subjectColistin
dc.subjectMeningitis
dc.subjectIntratechal
dc.titleVariables determining mortality in patients with Acinetobacter baumannii meningitis/ventriculitis treated with intrathecal colistin
dc.typeArticle

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