Hypoglycemic activity of capparis ovata desf. Var. palaestina zoh. methanol extract

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dc.authorid0000-0002-8084-7855
dc.contributor.authorOkur, Mehmet Evren
dc.contributor.authorÖzbek, Hanefi
dc.contributor.authorÇiçek Polat, Derya
dc.contributor.authorYılmaz, Sezen
dc.contributor.authorArslan, Rana
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:54Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:54Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractCaper (Capparis ovata Desf. and Capparis spinosa L.) is naturally widespread in Turkey. Traditionally, buds, fruits, seeds and roots of this plant are used as tonic, diuretic, anti-rheumatic, expectorant, antidiabetic, and antifungal. The aim of this study is to evaluate potential hypoglycemic effect of C. ovata var. palaestina extracts in alloxan-induced diabetic mice. For this purpose; diabetic mice were administered with 100, 300, 500 mg/kg (i.p.) doses of methanol extract of bud and fruit. Blood glucose levels were screened 60, 120, 240 and 360 min. after treatment. Furthermore, high resolution mass spectrometry (HRMS) analysis, ABTS and DPPH free radical scavenging activity test, and phenolic and flavonoid compounds analysis of extracts were carried out. The data obtained from in vivo study revealed that fruit-methanol 500 mg/kg (FM3), bud-methanol 300 mg/kg (BM2), bud-methanol 500 mg/kg (BM3) extracts showed significant hypoglycemic activity. All extracts indicated significant antioxidant activity, however bud-methanol (BM) extract demonstrated the most potent antioxidant activity. Moreover high levels of phenolic substances and flavonoids were involved in all extracts, but the highest levels were found in FM extract. HRMS study showed that rutin, quercetin 3-O-glucoside (isoquercitrin) and stachydrine substances had seen in BM extract. The results of this study showed that the C. ovata var. palaestina extracts which, indicate hypoglycemic, antioxidant activities, might provide additional support in diabetes.
dc.identifier.citationOkur, M., Özbek, H., Çiçek Polat, D., Yılmaz, S. ve Arslan, R. (2018). Hypoglycemic activity of capparis ovata desf. Var. palaestina zoh. methanol extract. Brazilian Journal of Pharmaceutical Sciences, 54(3). https://dx.doi.org/10.1590/s2175-97902018000318031
dc.identifier.doi10.1590/s2175-97902018000318031
dc.identifier.issn1984-8250
dc.identifier.issn2175-9790
dc.identifier.issue3
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1281
dc.identifier.urihttps://dx.doi.org/10.1590/s2175-97902018000318031
dc.identifier.volume54
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherFaculdade de Ciencias Farmaceuticas (Biblioteca)
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectC. Ovata Var
dc.subjectDiabetes Mellitus
dc.subjectMice
dc.subjectPalaestina/extract
dc.subjectPalaestina Hypoglycemic Effect Antioxidant Effects
dc.titleHypoglycemic activity of capparis ovata desf. Var. palaestina zoh. methanol extract
dc.typeArticle

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