Cinnamon polyphenol extract exerts neuroprotective activity in traumatic brain injury in male mice

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dc.authorid0000-0002-9704-6173
dc.authorid0000-0001-6494-8923
dc.authorid0000-0002-4051-2559
dc.authorid0000-0001-5134-1014
dc.authorid0000-0002-9013-2298
dc.contributor.authorYuluğ, Burak
dc.contributor.authorKılıç, Ertuğrul
dc.contributor.authorAltunay, Serdar
dc.contributor.authorErsavaş, Cenk
dc.contributor.authorOrhan, Cemal
dc.contributor.authorDalay, Arman
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorŞahin, Nurhan
dc.contributor.authorJuturu, Vijaya
dc.contributor.authorŞahin, Kazım
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:51:30Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:51:30Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.descriptionWOS: 000441417400005
dc.descriptionPubMed ID: 29714150
dc.description.abstractIntroduction: Cinnamon polyphenol extract is a traditional spice commonly used in different areas of the world for the treatment of different disease conditions which are associated with inflammation and oxidative stress. Despite many preclinical studies showing the anti-oxidative and anti-inflammatory effects of cinnamon, the underlying mechanisms in signaling pathways via which cinnamon protects the brain after brain trauma remained largely unknown. However, there is still no preclinical study delineating the possible molecular mechanism of neuroprotective effects cinnamon polyphenol extract in Traumatic Brain Injury (TBI). The primary aim of the current study was to test the hypothesis that cinnamon polyphenol extract administration would improve the histopathological outcomes and exert neuroprotective activity through its antioxidative and anti-inflammatory properties following TBI. Methods: To investigate the effects of cinnamon, we induced brain injury using a cold trauma model in male mice that were treated with cinnamon polyphenol extract (10 mg/kg) or vehicle via intraperitoneal administration just after TBI. Mice were divided into two groups: TBI+vehicle group and TBI+ cinnamon polyphenol extract group. Brain samples were collected 24 h later for analysis. Results: We have shown that cinnamon polyphenol extract effectively reduced infarct and edema formation which were associated with significant alterations in inflammatory and oxidative parameters, including nuclear factor-KB, interleukin 1-beta, interleukin 6, nuclear factor erythroid 2-related factor 2, glial fibrillary acidic protein, neural cell adhesion molecule, malondialdehyde, superoxide dismutase, catalase and glutathione peroxidase. Conclusion: Our results identify an important neuroprotective role of cinnamon polyphenol extract in TBI which is mediated by its capability to suppress the inflammation and oxidative injury. Further, specially designed experimental studies to understand the molecular cross-talk between signaling pathways would provide valuable evidence for the therapeutic role of cinnamon in TBI and other TBI related conditions.
dc.identifier.citationYuluğ, B., Kılıç, E., Altunay, S., Ersavaş, C., Orhan, C., Dalay, A. ... Şahin, K. (2018). Cinnamon polyphenol extract exerts neuroprotective activity in traumatic brain injury in male mice. Journal of Cns & Neurological Disorders-Drug Targets, 17(6), 439-447. https://dx.doi.org/10.2174/1871527317666180501110918
dc.identifier.doi10.2174/1871527317666180501110918
dc.identifier.endpage447
dc.identifier.issn1871-5273
dc.identifier.issn1996-3181
dc.identifier.issue6
dc.identifier.scopusqualityQ2
dc.identifier.startpage439
dc.identifier.urihttps://dx.doi.org/10.2174/1871527317666180501110918
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2227
dc.identifier.volume17
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBentham Science Publishers Ltd
dc.relation.ispartofCns & Neurological Disorders-Drug Targetsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCinnamon
dc.subjectTraumatic Brain Injury
dc.subjectGlial Fibrillary Acidic Protein
dc.subjectInterleukin 1-Beta
dc.subjectInterleukin 6
dc.subjectNeural Cell Adhesion Molecule
dc.subjectNuclear Factor-Kappa B
dc.subjectNuclear Factor Erythroid 2-Related Factor 2
dc.subjectMalondialdehyde
dc.subjectSuperoxide Dismutase
dc.subjectCatalase
dc.subjectGlutathione Peroxidase
dc.titleCinnamon polyphenol extract exerts neuroprotective activity in traumatic brain injury in male mice
dc.typeArticle

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