Clinical relevance of minor histocompatibility antigens

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dc.contributor.authorSavran Oğuz, Fatma
dc.contributor.authorKekik Çınar, Çiğdem
dc.contributor.authorOğuz, Seda B.
dc.contributor.authorSargın, Deniz
dc.contributor.authorKalayoğlu Beşışık, Sevgi
dc.date.accessioned2019-12-25T09:55:51Z
dc.date.available2019-12-25T09:55:51Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.descriptionConference Conference: 10th Eurasian Hematology Oncology Congress Location: Istanbul, TURKEY Date: OCT 08-11, 2019
dc.description.abstractObjective: The minor histocompatibility antigens (MiHA) are epitopes composed of polymorphic essential peptides evoking alloimmune responses limited to a variety of human leukocyte antigen (HLA) alleles. These peptides are allelic cellular proteins and encoded by autosomal genes or by genes of the Y chromosome. MiHAs may be immunogenic or nonimmunogenic in characteristic. They are either ubiquitously expressed in many cells and tissues or restricted to the hematopoietic system cells. Some of these MiHA can also be expressed by tumor cells. Upon hematopoietic stem cell transplantation (HSCT) for hematological malignancies responses to MiHA may develop as graft-versus-host-disease or graft rejection, but can also contribute to the eradication of the tumor cells named graft-versus.-leukemia effect. Our aim was to determine the MiHA distribution in Turkish healthy population and in patients with hematopoietic malignancies whereas some of them were genotypically identical HSCT recipient/donor pair.
dc.identifier.citationSavran Oğuz, F., Kekik Çınar, Ç., Oğuz S. B., Sargın D. ve Kalayoğlu Beşışık, S. (2019). Clinical relevance of minor histocompatibility antigens. 10th Eurasian Hematology Oncology Congress içinde (S28-S29. ss.). Istanbul, Turkey, October 08-11, 2019. https://doi.org/10.1016/S0145-2126(19)30265-6
dc.identifier.doi10.1016/S0145-2126(19)30265-6
dc.identifier.endpageS29
dc.identifier.issueSupplement: 1
dc.identifier.startpageS28
dc.identifier.urihttps://doi.org/10.1016/S0145-2126(19)30265-6
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4679
dc.identifier.volume85
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherPergamon-Elsevier Science
dc.relation.ispartof10th Eurasian Hematology Oncology Congressen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectHistocompatibility Antigens
dc.subjectClinical
dc.subjectMinor
dc.titleClinical relevance of minor histocompatibility antigens
dc.typeConference Object

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