Intrahepatic cholestasis of pregnancy: Spontaneous vs in vitro fertilization

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dc.authorid0000-0002-0901-9192
dc.contributor.authorBölükbaş, Filiz Füsun
dc.contributor.authorBölükbaş, Cengiz
dc.contributor.authorBalaban, Hatice Yasemin
dc.contributor.authorAygün, Cem
dc.contributor.authorİğnak, Seyda
dc.contributor.authorErgül, Emine
dc.contributor.authorYazıcıoğlu, Mehtap
dc.contributor.authorErşahin, Suat Süphan
dc.date.accessioned2020-07-21T07:17:12Z
dc.date.available2020-07-21T07:17:12Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractAim: Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disease in pregnancy. Although it was shown that multiple pregnancy and hormone therapies increase the risk of ICP, there is limited information that compared spontaneous fertilization and in vitro fertilization (IVF) from the aspect of developing ICP. In our study, we investigated the potential relationship between ICP and IVF/ spontaneous pregnancy.Materials and methods: We reviewed the records (between June 2007 and December 2014) of pregnancies with ICP who were referred to gastroenterology clinics in three different hospitals. Fifty-nine pregnancies (43 spontaneous fertilization, 16 IVF) with ICP were analyzed from the aspect of age, fertilization type, multiple/singleton pregnancy, delivery week, and biochemical results.Results: We found that serum bile acid levels were higher in the IVF group than the spontaneous fertilization group (32.8 ± 20 vs 19.6 ± 19 ?mol/L; p < 0.05). There was a significant inverse correlation between serum bile acid levels and gestational age (r = -0.42, p < 0.01) in the whole group. There was no difference between IVF and spontaneous fertilization groups in term of age, onset time of symptoms, serum alanine aminotransferase (ALT), alkaline phosphatase (ALP), total and direct bilirubin levels, prothrombin time (PT), international normalized ratio (INR), and platelet count.Conclusion: Our results suggest that the serum bile acid levels are higher in IVF than in spontaneous pregnancies with ICP, but its clinical implications are not clear. Further prospective studies with large number of ICP cases are needed to clarify the effect of IVF on ICP.
dc.identifier.citationBölükbaş, F. F., Bölükbaş, C., Balaban, H. Y., Aygün, C., İğnak, S., Ergül, E. ... Erşahin, S. S. (2017). Intrahepatic cholestasis of pregnancy: Spontaneous vs in vitro fertilization. Euroasian Journal of Hepato-Gastroenterology, 7(2), 126-129. https://dx.doi.org/10.5005/jp-journals-10018-1232
dc.identifier.doi10.5005/jp-journals-10018-1232
dc.identifier.endpage129
dc.identifier.issn2231-5047
dc.identifier.issn2231-5128
dc.identifier.issue2
dc.identifier.startpage126
dc.identifier.urihttps://dx.doi.org/10.5005/jp-journals-10018-1232
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5583
dc.identifier.volume7
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofEuroasian Journal of Hepato-Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 3.0 Unported*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/*
dc.subjectBile Acid
dc.subjectIn Vitro Fertilization
dc.subjectIntrahepatic Cholestasis of Pregnancy
dc.subjectPruritus
dc.subjectStillbirth
dc.titleIntrahepatic cholestasis of pregnancy: Spontaneous vs in vitro fertilization
dc.typeArticle

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