Neuroprotective effects of hemicraniectomy in malignant middle cerebral artery infarctions: Experimental study

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dc.contributor.authorAltıntaş, Özge
dc.contributor.authorAntar, Veysel
dc.contributor.authorBaran, Oğuz
dc.contributor.authorKarataş, Ersin
dc.contributor.authorAltıntaş, Mehmet Özgen
dc.contributor.authorKesgin, Sıdıka
dc.contributor.authorBüyükpınarbaşılı, Nur
dc.contributor.authorKoçyiğit, Abdurrahim
dc.contributor.authorAsil, Talip
dc.date.accessioned2020-03-11T07:27:06Z
dc.date.available2020-03-11T07:27:06Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.description.abstractBACKGROUND: Despite optimal medical therapy the mortality rate approaches 50% in MCA infarctions. Although recent studies have been showed life-saving effect of hemicraniectomy; there are a few data available in regard to neuroprotection effect of decompressive craniectomy (DC). We induced a malignant cerebral ischemia model by intraluminal permanent middle cerebral artery occlusion (MCAo) in male rats for defining the neuroprotective effects of early DC on brain-blood barrier (BBB) molecular changes, infarct size and cerebral edema. METHODS: A total of 48 male Spraque-Dawley rats were allocated to 4 groups; sham (N.=9). control (N.=9), experiment 1 (N.=15), experiment 2 (N.=15). DC was performed by creating a bone flap. after MCAo at 4 and 24 hours. After 28 hours of survival, all animals were sacrificed. Infarction volumes were calculated from TTC (2,3,5-triphenyl-2H-tetrazolium chloride)-stained brain sections. In all groups, cerebral edema was quantified as a change in the percentage of brain water content. Western Blot was used to analyze the expression of tight junction protein claudin-5 and occludin. RESULTS: Brain water content was calculated 75.18 +/- 0.75% in the early DC group and 77.76 +/- 0.71% in the late DC group. No significant difference was found between experiment groups (P=0.178). In the early DC group; occludin and claudin-5 were significantly expressed at higher levels compared to late DC group (occluding, P=0.013; claudin-5. P=0.034). At early DC group (73.38 +/- 23.11 mm(3)) the final infarct volumes were significantly smaller than in the late DC group (377.18 +/- 39.23 mm(3)) (P=0.013). CONCLUSIONS: The study results supported the neuroprotective effects of early DC in malignant MCA infarcts.
dc.identifier.citationAltıntaş, Ö., Antar, V., Baran, O., Karataş, E., Altıntaş, M. Ö., Kesgin, S. ... Asil, T. (2019). Neuroprotective effects of hemicraniectomy in malignant middle cerebral artery infarctions: Experimental study. Journal of Neurosurgical Science, 63(6), 714-722. http://doi.org/10.23736/S0390-5616.16.03444-5
dc.identifier.doi10.23736/S0390-5616.16.03444-5
dc.identifier.endpage722
dc.identifier.issn0390-5616
dc.identifier.issn1827-1855
dc.identifier.issue6
dc.identifier.scopusqualityQ2
dc.identifier.startpage714
dc.identifier.urihttp://doi.org/10.23736/S0390-5616.16.03444-5
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5023
dc.identifier.volume63
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherEdizioni Minerva Medica
dc.relation.ispartofJournal of Neurosurgical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectReperfusion
dc.subjectRat
dc.subjectOcclusion
dc.subjectTight Junction
dc.subjectFocal Ischemia
dc.subjectHemispheric Stroke
dc.subjectPathological Evaluation
dc.subjectDecompressive Craniectomy
dc.subjectAcute Ischemic-Stroke
dc.subjectBlood-Brain-Barrier
dc.titleNeuroprotective effects of hemicraniectomy in malignant middle cerebral artery infarctions: Experimental study
dc.typeArticle

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