Associations of trauma severity with mean platelet volume and levels of systemic inflammatory markers (IL1 beta, IL6, TNF alpha, and CRP)

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dc.contributor.authorAlper, Barış
dc.contributor.authorErdoğan, Barış
dc.contributor.authorErdoğan, Mehmet Özgür
dc.contributor.authorBozan, Korkut
dc.contributor.authorCan, Andmurat
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:42Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:42Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kulak Burun Boğaz Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000374424100001
dc.description.abstractWe investigated the associations of injury severity scores (ISSs) with the mean platelet volume, the serum levels of two interleukins (IL1 beta and IL6), and the serum levels of tumour necrosis factor-alpha (TNF alpha) and C-reactive protein (CRP). We sought to identify biochemical parameters that could be used as components of a new biochemical parameter-based ISS system. The levels of CRP, TNF alpha, IL1 beta, and IL6 differed significantly (all p values < 0.05) between severely injured patients and controls. The mean platelet volume (MPV) did not correlate with the ISSs (p > 0.05). The TNF alpha and IL6 levels were useful for determining the severity of injury, and the CRP level was elevated in all trauma patients but did not correlate with the ISS. The IL1 beta level was higher in the study group but did not increase as the ISS increased. IL6 and TNF alpha levels were higher in the study group and increased as the ISS increased. We found no significant difference between the trauma group and healthy individuals in terms of MPV values. IL6 and TNF alpha levels can be used to assess trauma severity. However, neither the MPV nor the CRP or IL1 beta level is useful for this purpose.
dc.identifier.citationAlper, B., Erdoğan, B., Erdoğan, M. Ö., Bozan, K. ve Can, A. (2016). Associations of trauma severity with mean platelet volume and levels of systemic inflammatory markers (IL1 beta, IL6, TNF alpha, and CRP). Mediators Of Inflammation. https://dx.doi.org/10.1155/2016/9894716
dc.identifier.doi10.1155/2016/9894716
dc.identifier.issn0962-9351
dc.identifier.issn1466-1861
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1155/2016/9894716
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3406
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHindawi Ltd
dc.relation.ispartofMediators Of Inflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAssociations of Trauma
dc.subjectMean Platelet
dc.subjectVolume and Levels of Systemic
dc.subjectInflammatory Markers
dc.titleAssociations of trauma severity with mean platelet volume and levels of systemic inflammatory markers (IL1 beta, IL6, TNF alpha, and CRP)
dc.typeArticle

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