Facial hypertrichosis in the course of isotretinoin treatment: four-year retrospective observation
| dc.contributor.author | Pekmezci, Erkin | |
| dc.date.accessioned | 2026-01-07T13:32:04Z | |
| dc.date.available | 2026-01-07T13:32:04Z | |
| dc.date.issued | 2024 | |
| dc.department | İstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | |
| dc.description.abstract | Background: isotretinoin is a synthetic retinoid used in the treatment of acne. There are limited and inconsistent data about the effects of isotretinoin on hormones and hair growth. Aim: to investigate a probable connection, a single center four-year retrospective data of female acne patients who were treated with oral isotretinoin and developed facial hypertrichosis was reported. Methods: in the years 2019-2023, 327 female patients between 16-33 years of age (Mean ± Standard Deviation: 23.4 ± 4.7) were treated with 0.5-0.8 mg/kg/day isotretinoin, approximately for 6 months (6.2 ± 0.8). The patients who developed facial hypertrichosis were additionally analysed for dehydroepiandrosterone sulfate, prolactin and thyroid stimulating hormone values. Results: thirty one patients (9.5%) in all ages (22.9 ± 4.3) declared excessive hair growth on cheeks and/or chin during treatment. All declarations were between the 2nd and 4th months (2.6 ± 0.8). The mean values of analysed hormones were in normal ranges. Twenty seven of the thirty one patients (87%) stated that the excessive hair growth terminated completely at the end of 4th month (3.1 ± 0.7) after the cessation of the treatment, and the others declared it was diminished to a great extent. Conclusions: mainly due to normal mean values of the analysed hormones, it is hard to consider that the cause of hypertrichosis is hormonal irregularity. However, 9.5% is a considerable ratio. A more extensive prospective study should be performed to reveal the cause of this phenomenon. | |
| dc.identifier.citation | Pekmezci, E. (2024). Facial hypertrichosis in the course of isotretinoin treatment: four-year retrospective observation. Aesthetic Medicine, 10(4). http://dx.doi.org/10.57662/am.v10i4.16255 | |
| dc.identifier.doi | 10.57662/am.v10i4.16255 | |
| dc.identifier.issue | 4 | |
| dc.identifier.scopus | 2-s2.0-85213315508 | |
| dc.identifier.scopusquality | Q4 | |
| dc.identifier.uri | http://dx.doi.org/10.57662/am.v10i4.16255 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/13358 | |
| dc.identifier.volume | 10 | |
| dc.indekslendigikaynak | Scopus | |
| dc.institutionauthor | Pekmezci, Erkin | |
| dc.institutionauthorid | 0000-0003-1469-2557 | |
| dc.language.iso | en | |
| dc.relation.ispartof | Aesthetic Medicine | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Facial Hypertrichosis | |
| dc.subject | Hirsutism | |
| dc.subject | Isotretinoin | |
| dc.title | Facial hypertrichosis in the course of isotretinoin treatment: four-year retrospective observation | |
| dc.type | Article |
