The rate of oocytes with granular cytoplasm is higher in women with endometrioma in ICSI cycles

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dc.authorid0000-0003-2143-5268
dc.contributor.authorBilgiç, Bülent Emre
dc.contributor.authorKürek Eken, Meryem
dc.contributor.authorAyla, Şule
dc.contributor.authorKöse, Ayşe
dc.contributor.authorKutlu, Tayfun
dc.contributor.authorİlhan, Gülşah
dc.date.accessioned2023-01-17T12:34:13Z
dc.date.available2023-01-17T12:34:13Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractThe purpose of this study was to investigate the impact of endometrioma on oocyte morphology and fertility outcome in intracytoplasmic sperm injection (ICSI)cycles. The study material was obtained from 114 ICSI cycles of infertile women aged between 20 and 38 years with ovarian endometriomas and unexplained infertility. In total, 644 mature oocytes were included in the analysis. The rates of specific oocyte morphological abnormalities were similar between the two groups however the central granulation rate was significantly higher in the group with endometrioma (p <.05). Fertilisation rate were not significantly different between the groups (p ?.05) however the numbers of metaphase 2 (MII) oocytes and embryos were lower in the endometrioma group (p ?.05). Endometrioma was associated with a higher rate of oocytes with granular cytoplasm, despite the fertilisation rate the numbers of the MII oocytes and embryo were affected.IMPACT STATEMENTWhat is already known on this subject? The association between endometrioma and infertility is a well-known condition, but the possible mechanisms of the effects of endometrioma on women's fertility is still debated and controversial. There is limited data on the effect of endometrioma on oocyte morphology. Low oocyte quality and lower fertilisation rates might be the main cause of adverse pregnancy outcomes during in vitro fertilisation/intracytoplasmic sperm injection cycles. What do the results of this study add? Endometrioma was associated with a higher rate of oocytes with granular cytoplasm, and lower metaphase 2 oocytes and embryos. What are the implications of these findings for clinical practice and/or further research? Future studies using further oocyte quality assessment methods and prospective observational studies including live-birth rate should be designed to better understand how endometrioma affects fertility outcomes.
dc.identifier.citationBilgiç, B. E., Kürek Eken, M., Ayla, Ş., Köse, A., Kutlu, T. ve İlhan, G. (2022). The rate of oocytes with granular cytoplasm is higher in women with endometrioma in ICSI cycles. Journal of Obstetrics and Gynaecology, 42(3), 467-471. https://dx.doi.org/10.1080/01443615.2021.1916803
dc.identifier.doi10.1080/01443615.2021.1916803
dc.identifier.endpage471
dc.identifier.issn0144-3615
dc.identifier.issn1364-6893
dc.identifier.issue3
dc.identifier.pmid34165007
dc.identifier.scopus2-s2.0-85108618201
dc.identifier.scopusqualityQ3
dc.identifier.startpage467
dc.identifier.urihttps://dx.doi.org/10.1080/01443615.2021.1916803
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10321
dc.identifier.volume42
dc.identifier.wos000665649900001en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAyla, Şule
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Obstetrics and Gynaecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectEndometrioma
dc.subjectFertilisationrate
dc.subjectOocytemorphology
dc.subjectEmbryos
dc.titleThe rate of oocytes with granular cytoplasm is higher in women with endometrioma in ICSI cycles
dc.typeArticle

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