The effects of supraphysiological oestrogen levels on ventricular repolarisation parameters

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dc.contributor.authorYiğiner, Ömer
dc.contributor.authorDoğan, Mehmet
dc.contributor.authorGün, İsmet
dc.contributor.authorKutlu, Hüseyin Tayfun
dc.contributor.authorDeğirmencioğlu, Gökhan
dc.contributor.authorGüliyev, İlkin
dc.contributor.authorTokatlı, Alptuğ
dc.contributor.authorKılıçaslan, Fethi
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:35Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:35Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.descriptionWOS: 000435195800008
dc.descriptionPubMed ID: 29399762
dc.description.abstractBackground: The frequency of arrhythmic death developing without a structural cardiac disease is higher in women. Also, female sex is an independent risk factor regarding development of torsades de pointes. Several studies have been conducted on the physiological and therapeutic effects of sex hormones on the cardiac conduction system. Aim: In this study we aim to examine the effect of hormonal changes, especially supraphysiological E2 level changes occurring during in vitro fertilisation treatment, on ventricular repolarisation parameters. Methods: The study included female patients aged between 23 and 39 years, who were administered controlled ovarian hyperstimulation treatment. Patients' electrocardiograms and blood samples were obtained and analysed before and after the ovarian hyperstimulation treatment. Results: Mean QTc intervals before ovarian hyperstimulation were 411.9 +/- 23.7 ms. Measurements during oestradiol peak were calculated as 420.7 +/- 23.3 ms, and the QTc interval increase was significant (p = 0.007). Corrected QT dispersion averages were not significant before or after hyperstimulation (53 +/- 17 ms vs. 54.5 +/- 18.2 ms, respectively, p > 0.05). Tp-e, J-T peak, and PR dispersion changes were not significant after the ovarian hyperstimulation therapy. Conclusions: Supraphysiological oestradiol levels that occur during controlled ovarian hyperstimulation cause prolongation of QTc intervals, but not to a pathological level. Although this prolongation is not significant in healthy individuals, it might increase ventricular arrhythmia risk in patients with congenital long QT syndrome and in patients taking medication that prolongs QT.
dc.identifier.citationYiğiner, Ö., Doğan, M., Gün, İ., Kutlu, H. T., Değirmencioğlu, G., Güliyev, İ. ... Kılıçaslan, F. (2018). The effects of supraphysiological oestrogen levels on ventricular repolarisation parameters. Kardiologia Polska, 76(6), 974-979. https://dx.doi.org/10.5603/KP.a2018.0037
dc.identifier.doi10.5603/KP.a2018.0037
dc.identifier.endpage979
dc.identifier.issn0022-9032
dc.identifier.issn1897-4279
dc.identifier.issue6
dc.identifier.scopusqualityQ3
dc.identifier.startpage974
dc.identifier.urihttps://dx.doi.org/10.5603/KP.a2018.0037
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3353
dc.identifier.volume76
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVia Medica
dc.relation.ispartofKardiologia Polskaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOestrogen
dc.subjectQT Interval
dc.subjectQT Dispersion
dc.subjectVentricular Repolarisation
dc.subjectOvulation Induction
dc.subjectIn Vitro Fertilisation
dc.titleThe effects of supraphysiological oestrogen levels on ventricular repolarisation parameters
dc.typeArticle

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