Emulsomes meet s-layer proteins: An emerging targeted drug delivery system

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dc.authorid0000-0001-9434-3861
dc.contributor.authorÜçışık, Mehmet Hikmet
dc.contributor.authorSleytr, Uwe Bernd
dc.contributor.authorSchuster, Bernhard
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:51:44Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:51:44Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümü
dc.descriptionWOS: 000349958000011
dc.descriptionPubMed ID: 25697368
dc.description.abstractHere, the use of emulsomes as a drug delivery system is reviewed and compared with other similar lipidic nanoformulations. In particular, we look at surface modification of emulsomes using S-layer proteins, which are self-assembling proteins that cover the surface of many prokaryotic organisms. It has been shown that covering emulsomes with a crystalline S-layer lattice can protect cells from oxidative stress and membrane damage. In the future, the capability to recrystallize S-layer fusion proteins on lipidic nanoformulations may allow the presentation of binding functions or homing protein domains to achieve highly specific targeted delivery of drug-loaded emulsomes. Besides the discussion on several designs and advantages of composite emulsomes, the success of emulsomes for the delivery of drugs to fight against viral and fungal infections, dermal therapy, cancer, and autoimmunity is summarized. Further research might lead to smart, biocompatible emulsomes, which are able to protect and reduce the side effects caused by the drug, but at the same time are equipped with specific targeting molecules to find the desired site of action.
dc.description.sponsorshipAir Force Office of Scientific Research (AFOSR) [FA9550-09-0342, FA9550-10-1-0223]; Austrian Science Fund (FWF) [P20256-B11]en_US
dc.description.sponsorshipThe work was supported by Air Force Office of Scientific Research (AFOSR), Agreement Award Nr.: FA9550-09-0342 and Agreement Award Nr.: FA9550-10-1-0223, and the Austrian Science Fund (FWF), project P20256-B11. The authors wish to thank Dr. Gary Dorken from Institute for Biologically Inspired Materials (Department of Nanobio-technology, University of Natural Resources and Life Sciences (BOKU) Vienna) for assistance in the proof-reading of the manuscript.en_US
dc.identifier.citationÜçışık, M. H., Sleytr, U. B. ve Schuster, B. (2015). Emulsomes meet s-layer proteins: An emerging targeted drug delivery system. Current Pharmaceutical Biotechnology, 16(4), 392-405. https://dx.doi.org/10.2174/138920101604150218112656
dc.identifier.doi10.2174/138920101604150218112656
dc.identifier.endpage405
dc.identifier.issn1389-2010
dc.identifier.issn1873-4316
dc.identifier.issue4
dc.identifier.scopusqualityQ1
dc.identifier.startpage392
dc.identifier.urihttps://dx.doi.org/10.2174/138920101604150218112656
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2274
dc.identifier.volume16
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBentham Science Publishers
dc.relation.ispartofCurrent Pharmaceutical Biotechnologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDrug Delivery System
dc.subjectEmulsome
dc.subjectLipid Nanoparticles
dc.subjectNanomedicine
dc.subjectS-layer Proteins
dc.titleEmulsomes meet s-layer proteins: An emerging targeted drug delivery system
dc.typeArticle

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