How does pregnancy affect the patients with pituitary adenomas: A study on 113 pregnancies from Turkey

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dc.contributor.authorCihan Karaca, Züleyha
dc.contributor.authorYarman, Sema
dc.contributor.authorÖzbaş, I.
dc.contributor.authorKadıoğlu, Pınar
dc.contributor.authorAktürk, Müjde
dc.contributor.authorKılıçlı, Fatih
dc.contributor.authorDökmetaş, Hatice Sebile
dc.contributor.authorÇolak, Ramis
dc.contributor.authorAtmaca, Hulusi
dc.contributor.authorCantürk, Zeynep
dc.contributor.authorAltuntaş, Yüksel
dc.contributor.authorÇolak Özbey, Neşe
dc.contributor.authorHatipoğlu, Nihal
dc.contributor.authorTanrıverdi, Fatih
dc.contributor.authorÜnlühızarcı, Kürşad
dc.contributor.authorKeleştimur, Fahrettin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:58:01Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:58:01Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000419489200014
dc.descriptionPubMed ID: 28634705
dc.description.abstractObjective Data regarding pregnancies in relation to pituitary tumors are limited. The effects of pregnancy on pituitary adenomas and the effects of adenoma itself (hormonal activity, mass effects and pituitary insufficiency) and/or treatment on the ongoing gestation and developing fetus were evaluated. Methods The study was a retrospective study. A questionnaire involving questions regarding medical history before index gestation, history of related pregnancy, result of index gestation and postpartum follow-up of the patients was filled by the investigator in one of the eight Referral Endocrinology Centers from Turkey. Results One hundred and thirteen (83 prolactinoma, 21 acromegaly, 8 NFPA and 1 plurihormonal pituitary adenoma) pregnancies of 87 (60 prolactinoma, 19 acromegaly, 7 NFPA and 1 plurihormonal pituitary adenoma) patients were reviewed. The clinically important pregnancy-related tumor growth of pituitary adenomas was found to be low in previously treated adenomas. Prolactinomas were more likely to increase in size during pregnancy especially if effective prior treatment was lacking. The risk of hypopituitarism is also minimal due to pituitary adenomas during pregnancy. The results of pregnancies did not differ in patients who were on medical treatment or not for prolactinomas and acromegaly during gestation. Neural tube defect and microcephaly associated with maternal cabergoline use; Down syndrome and corpus callosum agenesis associated with maternal bromocriptine use; unilateral congenital cataract, craniosynostosis and microcephaly associated with maternal acromegaly were detected for the first time. Conclusion Medical treatment can be safely done stopped in patients with prolactinoma and acromegaly when pregnancy is confirmed and reinstituted when necessary. Prospective studies may help to determine the effects of medical treatment during gestation on the mother and fetus.
dc.identifier.citationCihan Karaca, Z., Yarman, S., Özbaş, I., Kadıoğlu, P., Aktürk, M., Kılıçlı, F. ... Keleştimur, F. (2018). How does pregnancy affect the patients with pituitary adenomas: A study on 113 pregnancies from Turkey. Journal of Endocrinological Investigation, 41(1), 129-141. https://dx.doi.org/10.1007/s40618-017-0709-8
dc.identifier.doi10.1007/s40618-017-0709-8
dc.identifier.endpage141
dc.identifier.issn1720-8386
dc.identifier.issue1
dc.identifier.scopusqualityQ3
dc.identifier.startpage129
dc.identifier.urihttps://dx.doi.org/10.1007/s40618-017-0709-8
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3091
dc.identifier.volume41
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Endocrinological Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectPregnancy
dc.subjectPituitary
dc.subjectAcromegaly
dc.subjectProlactinoma
dc.subjectAdenoma
dc.titleHow does pregnancy affect the patients with pituitary adenomas: A study on 113 pregnancies from Turkey
dc.typeArticle

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