Ozone therapy as a novel complementary therapeutic approach in refractory idiopathic granulomatous mastitis

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dc.contributor.authorCabıoğlu, Neslihan
dc.contributor.authorCan Trabulus, Didem
dc.contributor.authorEmiroğlu, Selman
dc.contributor.authorÖzkurt, Enver
dc.contributor.authorYalçın, Nesli
dc.contributor.authorDinç, Nagehan
dc.contributor.authorTükenmez, Mustafa
dc.contributor.authorMüslümanoğlu, Mahmut
dc.contributor.authorİğci, Abdullah
dc.contributor.authorÖzmen, Vahit
dc.contributor.authorDinççağ, Ahmet Sait
dc.contributor.authorGüven, Yusuf İzzettin
dc.date.accessioned2023-08-07T12:48:58Z
dc.date.available2023-08-07T12:48:58Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sürekli Eğitim Merkezi (SEM)
dc.description.abstractBackground: Autoimmunity may play a major role in the pathogenesis of idiopathic granulomatous mastitis (IGM). The therapeutic potential of ozone therapy has recently been shown in rheumatological diseases, and this study aimed to assess the clinical efficacy of ozone therapy (OT) in refractory IGM. Methods: Patients with biopsy-verified IGM and incomplete response after steroid therapy (n = 47) between 2018 and 2021 were enrolled. Of these, 23 cases in cohort A had standard treatment with further steroid therapy (ST), and 24 were treated with systemic OT via autohemotherapy (AHT) in addition to steroid therapy (cohort B). Results: The median age was 33 years (range, 24–45). Patients in cohort B had a higher complete response rate after completion of a four-month ozone therapy than those in the ST-group (OT-group, 37.5% vs. ST-group, 0%; p = 0.002). At a median follow-up of 12 months (range, 12–35), the patients treated with OT had a lower one-year recurrence in the affected breast than cases in cohort A treated with ST (OT-group, 21% vs. ST-group, 70%; p = 0.001). No significant side effects were observed in patients in cohort B related to AHT. Furthermore, OT significantly decreased the total steroid treatment duration (median week of steroid use; 26 weeks in cohort A vs. 12 weeks in cohort B; p = 0.001). Conclusion: Systemic OT increases the complete response rate and decreases the duration of steroid treatment in patients with refractory IGM. Therefore, ozone therapy is an effective, well-tolerated, and safe novel complementary therapeutic modality.
dc.description.sponsorshipIstanbul Breast Societyen_US
dc.identifier.citationCabıoğlu, N., Can Trabulus, D., Emiroğlu, S., Özkurt, E., Yalçın, N., Dinç, N. ... Güven, Y. İ. (2023). Ozone therapy as a novel complementary therapeutic approach in refractory idiopathic granulomatous mastitis. Frontiers in Medicine, 10. https://dx.doi.org/10.3389/fmed.2023.1174372
dc.identifier.doi10.3389/fmed.2023.1174372
dc.identifier.issn2296-858X
dc.identifier.pmid37484853
dc.identifier.scopus2-s2.0-85165164250
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.3389/fmed.2023.1174372
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11280
dc.identifier.volume10
dc.identifier.wos001029422700001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüven, Yusuf İzzettin
dc.language.isoen
dc.publisherFrontiers Media SA
dc.relation.ispartofFrontiers in Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIdiopathic Granulomatous Mastitis
dc.subjectOzone Therapy
dc.subjectRefractory Granulomatous Mastitis
dc.subjectSteroid
dc.subjectSteroid Resistance
dc.titleOzone therapy as a novel complementary therapeutic approach in refractory idiopathic granulomatous mastitis
dc.typeArticle

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