Investigation into the effects of prenatal alcohol exposure on postnatal spine development and expression of synaptophysin and PSD95 in rat hippocampus

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dc.authorid0000-0001-6494-8923
dc.contributor.authorElibol-Can, Birsen
dc.contributor.authorKılıç, Ertuğrul
dc.contributor.authorYürüker, Sinan
dc.contributor.authorJakubowska-Doğru, Ewa
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:39Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:39Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.descriptionWOS: 000333002800014
dc.descriptionPubMed ID: 24365761
dc.description.abstractEthanol is known as a potent teratogen responsible for the fetal alcohol syndrome characterized by cognitive deficits especially pronounced in juveniles but ameliorating in adults. Since the mechanisms of these deficits and following partial recovery are not fully elucidated, the aim of the present study was to investigate the process of synaptogenesis in the hippocampus over the first two months of life in control and fetal-alcohol rats. Ethanol was delivered to the pregnant dams by intragastric intubation throughout 7-21 gestation days at the daily dose of 6 g/kg generating a mean blood alcohol level of 246.6 +/- 40.9 mg/dl on gestation day 20. The spine densities as well as the expression of pre- and postsynaptic proteins, synaptophysin (SYP) and PSD-95 protein, were evaluated for three distinct hippocampal regions: CA1, CA2+3, and DG and four postnatal days: PD1, PD10, PD30 and PD60, independently. Our results confirmed an intensive synaptogenesis within the brain spurt period (first 10 postnatal days), however, the temporal pattern of changes in the SYP and PSD-95 expression was different. The ethanol exposure during half of the 1st and the whole 2nd human trimester equivalent resulted in an overall trend toward lower values of synaptic indices at PD1 with a fast recovery from these deficits observed already at PD10. At PD30, around the age when the most pronounced behavioral deficits have been previously reported in juvenile fetal-alcohol subjects, no significant changes were found in either the hippocampal levels of synaptic proteins or in the spine density in principal hippocampal neurons. (C) 2013 ISDN. Published by Elsevier Ltd. All rights reserved.
dc.description.sponsorshipMETU Scientific Research Founden_US
dc.description.sponsorshipTurkish Scientific and Technical Council (TUBITAK)en_US
dc.description.sponsorshipThe study was supported by the METU Scientific Research Found and by the grant from the Turkish Scientific and Technical Council (TUBITAK), SBAG-107S069 to EJD and by the TUBITAK PhD scholarship given to BEC. The authors would like to thank Signem Eyuboglu-Dinc for her kindly guidance and help with experimental protocols applied in this study.en_US
dc.identifier.citationElibol-Can, B., Kılıç, E., Yürüker, S. ve Jakubowska-Dogru, E. (2014). Investigation into the effects of prenatal alcohol exposure on postnatal spine development and expression of synaptophysin and PSD95 in rat hippocampus. International Journal of Developmental Neuroscience, 33, 106-114. https://dx.doi.org/10.1016/j.ijdevneu.2013.12.003
dc.identifier.doi10.1016/j.ijdevneu.2013.12.003
dc.identifier.endpage114
dc.identifier.issn0736-5748
dc.identifier.issn1873-474X
dc.identifier.scopusqualityQ2
dc.identifier.startpage106
dc.identifier.urihttps://dx.doi.org/10.1016/j.ijdevneu.2013.12.003
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2776
dc.identifier.volume33
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Journal of Developmental Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/107S069
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectFetal Ethanol
dc.subjectSynaptophysin
dc.subjectPSD-95
dc.subjectSpine Counts
dc.subjectHippocampus
dc.subjectRat
dc.titleInvestigation into the effects of prenatal alcohol exposure on postnatal spine development and expression of synaptophysin and PSD95 in rat hippocampus
dc.typeArticle

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