Resting-state electroencephalographic rhythms depend on sex in patients with dementia due to parkinson's and lewy body diseases an exploratory study

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dc.contributor.authorDel Percio, Claudio
dc.contributor.authorLizio, Roberta
dc.contributor.authorLopez, Susanna
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorHelvacı Yılmaz, Nesrin
dc.contributor.authorBabiloni, Claudio
dc.date.accessioned2026-04-15T12:49:58Z
dc.date.available2026-04-15T12:49:58Z
dc.date.issued2025
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı
dc.description.abstractParkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB) are more prevalent in males than females. Furthermore, they typically showed abnormally high delta (< 4 Hz) and low alpha (8–10 Hz) rhythms from resting-state electroencephalographic (rsEEG) activity. Here, we hypothesized that those abnormalities may depend on the patient's sex. An international database provided clinical-demographic-rsEEG datasets for cognitively unimpaired older (Healthy; N = 49; 24 females), PDD (N = 39; 13 females), and DLB (N = 38; 15 females) participants. Each group was stratified into matched female and male subgroups. The rsEEG rhythms were investigated across the individual rsEEG delta, theta, and alpha frequency bands based on the individual alpha frequency peak. The eLORETA freeware was used to estimate cortical rsEEG sources. In the Healthy group, widespread rsEEG alpha source activities were greater in the females than in the males. In the PDD group, widespread rsEEG delta source activities were lower and widespread rsEEG alpha source activities were greater in the females than in the males. In the DLB group, central-parietal rsEEG delta source activities were lower, and posterior rsEEG alpha source activities were greater in the females than in the males. These results suggest sex-dependent hormonal modulation of neuroprotective-compensatory neurophysiological mechanisms in PDD and DLB patients underlying the generation of rsEEG delta and alpha rhythms, which should be considered in the treatment of vigilance dysregulation in those patients.
dc.description.sponsorshipCall "Annual Strategic Program of the Ital-ian Ministry of University and Research ; Ministry of Education, Universities and Research (MIUR)
dc.identifier.citationDel Percio, C., Lizio, R., Lopez, S., Güntekin, B., Hanoğlu, L., Helvacı Yılmaz, N. ... Babiloni, C. (2025). Resting-state electroencephalographic rhythms depend on sex in patients with dementia due to parkinson's and lewy body diseases an exploratory study. Neurobiology of Disease, 206. http://dx.doi.org/10.1016/j.nbd.2025.106807
dc.identifier.doi10.1016/j.nbd.2025.106807
dc.identifier.issn0969-9961
dc.identifier.issn1095-953X
dc.identifier.pmid39855475
dc.identifier.scopus2-s2.0-85216068242
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.1016/j.nbd.2025.106807
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13426
dc.identifier.volume206
dc.identifier.wosWOS:001416306300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüntekin, Bahar
dc.institutionauthorHanoğlu, Lütfü
dc.institutionauthorHelvacı Yılmaz, Nesrin
dc.institutionauthorid0000-0002-0860-0524
dc.institutionauthorid0000-0003-4292-5717
dc.institutionauthorid0000-0001-7566-1063
dc.language.isoen
dc.relation.ecinfo:eu-repo/grantAgreement/EC/FP7/2022FJAXY8
dc.relation.ecinfo:eu-repo/grantAgreement/EC/FP7/2010SH7H3F
dc.relation.ispartofNeurobiology of Disease
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectExact Low-Resolution Brain Electromagnetic Source Tomography (Eloreta)
dc.subjectLewy Body Dementia (DLB)
dc.subjectParkinson's Disease Dementia (PDD)
dc.subjectResting-State Electroencephalographic (EEG) Rhythms
dc.subjectSex
dc.titleResting-state electroencephalographic rhythms depend on sex in patients with dementia due to parkinson's and lewy body diseases an exploratory study
dc.typeArticle

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